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Current Knowledge about Mechanisms of Drug Resistance against ALK Inhibitors in Non-Small Cell Lung Cancer.
Smolle, Elisabeth; Taucher, Valentin; Lindenmann, Joerg; Jost, Philipp J; Pichler, Martin.
Afiliación
  • Smolle E; Division of Pulmonology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria.
  • Taucher V; Division of Cardiology, Department of Internal Medicine, Hospital Barmherzige Schwestern Ried, 4910 Ried, Austria.
  • Lindenmann J; Department of Thoracic Surgery, University Clinic of Surgery, Medical University of Graz, 8036 Graz, Austria.
  • Jost PJ; Division of Oncology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria.
  • Pichler M; Medical Department III of Hematology and Oncology, Klinikum rechts der Isar, Technical University Munich, 81675 Munich, Germany.
Cancers (Basel) ; 13(4)2021 Feb 09.
Article en En | MEDLINE | ID: mdl-33572278
Non-small cell lung cancer (NSCLC) accounts for the majority of lung cancer subtypes. Two to seven percent of NSCLC patients harbor gene rearrangements of the anaplastic lymphoma kinase (ALK) gene or, alternatively, harbor chromosomal fusions of ALK with echinoderm microtubule-associated protein-like 4 (EML4). The availability of tyrosine kinase inhibitors targeting ALK (ALK-TKIs) has significantly improved the progression-free and overall survival of NSCLC patients carrying the respective genetic aberrations. Yet, increasing evidence shows that primary or secondary resistance to ALK-inhibitors during the course of treatment represents a relevant clinical problem. This necessitates a switch to second- or third-generation ALK-TKIs and a close observation of NSCLC patients on ALK-TKIs during the course of treatment by repetitive molecular testing. With this review of the literature, we aim at providing an overview of current knowledge about resistance mechanisms to ALK-TKIs in NSCLC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancers (Basel) Año: 2021 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancers (Basel) Año: 2021 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Suiza