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Catalytic Nanozyme for Radiation Protection.
Zhao, Ruiying; Liu, Haile; Li, Yongming; Guo, Meili; Zhang, Xiao-Dong.
Afiliación
  • Zhao R; Department of Physics, School of Science, Tianjin Chengjian University, Tianjin 300384, China.
  • Liu H; Department of Physics and Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, Institute of Advanced Materials Physics, School of Science, Tianjin University, Tianjin 300350, China.
  • Li Y; Tianjin Key Laboratory of Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300192, China.
  • Guo M; Department of Physics, School of Science, Tianjin Chengjian University, Tianjin 300384, China.
  • Zhang XD; Department of Physics and Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, Institute of Advanced Materials Physics, School of Science, Tianjin University, Tianjin 300350, China.
Bioconjug Chem ; 32(3): 411-429, 2021 03 17.
Article en En | MEDLINE | ID: mdl-33570917
Radiotherapy has been widely used in clinical cancer treatment. However, the ionizing radiation required to kill the tumor will inevitably cause damage to the surrounding normal tissues. To minimize the radiation damage and side effects, small molecular radioprotective agents have been used as clinical adjuvants for radiation protection of healthy tissues. However, the shortcomings of small molecules such as short circulation time and rapid kidney clearance from the body greatly hinder their biomedical applications. In recent years, nanozymes have attracted much attention because of their potential to treat a variety of diseases. Nanozymes exhibit catalytic properties and antioxidant capabilities to provide a potential solution for the development of high-efficiency radioprotective agents in radiotherapy and nuclear radiation accidents. Therefore, in this review, we systematically summarize the catalytic nanozymes used for radiation protection of healthy tissues and discuss the challenges and future prospects of nanomaterials in the field of radiation protection.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Protección Radiológica / Nanoestructuras / Enzimas Límite: Animals Idioma: En Revista: Bioconjug Chem Asunto de la revista: BIOQUIMICA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Protección Radiológica / Nanoestructuras / Enzimas Límite: Animals Idioma: En Revista: Bioconjug Chem Asunto de la revista: BIOQUIMICA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos