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Recent African strains of Zika virus display higher transmissibility and fetal pathogenicity than Asian strains.
Aubry, Fabien; Jacobs, Sofie; Darmuzey, Maïlis; Lequime, Sebastian; Delang, Leen; Fontaine, Albin; Jupatanakul, Natapong; Miot, Elliott F; Dabo, Stéphanie; Manet, Caroline; Montagutelli, Xavier; Baidaliuk, Artem; Gámbaro, Fabiana; Simon-Lorière, Etienne; Gilsoul, Maxime; Romero-Vivas, Claudia M; Cao-Lormeau, Van-Mai; Jarman, Richard G; Diagne, Cheikh T; Faye, Oumar; Faye, Ousmane; Sall, Amadou A; Neyts, Johan; Nguyen, Laurent; Kaptein, Suzanne J F; Lambrechts, Louis.
Afiliación
  • Aubry F; Insect-Virus Interactions Unit, Institut Pasteur, UMR2000, CNRS, Paris, France.
  • Jacobs S; KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
  • Darmuzey M; GIGA-Stem Cells/GIGA-Neurosciences, Interdisciplinary Cluster for Applied Genoproteomics (GIGA-R), C.H.U. Sart Tilman, University of Liège, Liège, Belgium.
  • Lequime S; KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Clinical and Epidemiological Virology, Leuven, Belgium.
  • Delang L; Cluster of Microbial Ecology, Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, The Netherlands.
  • Fontaine A; KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven, Belgium.
  • Jupatanakul N; Unité Parasitologie et Entomologie, Département Microbiologie et Maladies Infectieuses, Institut de Recherche Biomédicale des Armées (IRBA), Marseille, France.
  • Miot EF; IRD, SSA, AP-HM, UMR Vecteurs-Infections Tropicales et Méditerranéennes (VITROME), Aix Marseille University, Marseille, France.
  • Dabo S; IHU Méditerranée Infection, Marseille, France.
  • Manet C; Insect-Virus Interactions Unit, Institut Pasteur, UMR2000, CNRS, Paris, France.
  • Montagutelli X; National Center for Genetic Engineering and Biotechnology (BIOTEC), Pathum Thani, Thailand.
  • Baidaliuk A; Insect-Virus Interactions Unit, Institut Pasteur, UMR2000, CNRS, Paris, France.
  • Gámbaro F; Insect-Virus Interactions Unit, Institut Pasteur, UMR2000, CNRS, Paris, France.
  • Simon-Lorière E; Mouse Genetics Laboratory, Institut Pasteur, Paris, France.
  • Gilsoul M; Mouse Genetics Laboratory, Institut Pasteur, Paris, France.
  • Romero-Vivas CM; Insect-Virus Interactions Unit, Institut Pasteur, UMR2000, CNRS, Paris, France.
  • Cao-Lormeau VM; Evolutionary Genomics of RNA Viruses Group, Institut Pasteur, Paris, France.
  • Jarman RG; Evolutionary Genomics of RNA Viruses Group, Institut Pasteur, Paris, France.
  • Diagne CT; Evolutionary Genomics of RNA Viruses Group, Institut Pasteur, Paris, France.
  • Faye O; GIGA-Stem Cells/GIGA-Neurosciences, Interdisciplinary Cluster for Applied Genoproteomics (GIGA-R), C.H.U. Sart Tilman, University of Liège, Liège, Belgium.
  • Faye O; Laboratorio de Enfermedades Tropicales, Departamento de Medicina, Fundación Universidad del Norte, Barranquilla, Colombia.
  • Sall AA; Institut Louis Malardé, Papeete, Tahiti, French Polynesia.
  • Neyts J; Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Nguyen L; Arbovirus and Viral Hemorrhagic Fevers Unit, Institut Pasteur Dakar, Dakar, Senegal.
  • Kaptein SJF; Arbovirus and Viral Hemorrhagic Fevers Unit, Institut Pasteur Dakar, Dakar, Senegal.
  • Lambrechts L; Arbovirus and Viral Hemorrhagic Fevers Unit, Institut Pasteur Dakar, Dakar, Senegal.
Nat Commun ; 12(1): 916, 2021 02 10.
Article en En | MEDLINE | ID: mdl-33568638
The global emergence of Zika virus (ZIKV) revealed the unprecedented ability for a mosquito-borne virus to cause congenital birth defects. A puzzling aspect of ZIKV emergence is that all human outbreaks and birth defects to date have been exclusively associated with the Asian ZIKV lineage, despite a growing body of laboratory evidence pointing towards higher transmissibility and pathogenicity of the African ZIKV lineage. Whether this apparent paradox reflects the use of relatively old African ZIKV strains in most laboratory studies is unclear. Here, we experimentally compare seven low-passage ZIKV strains representing the recently circulating viral genetic diversity. We find that recent African ZIKV strains display higher transmissibility in mosquitoes and higher lethality in both adult and fetal mice than their Asian counterparts. We emphasize the high epidemic potential of African ZIKV strains and suggest that they could more easily go unnoticed by public health surveillance systems than Asian strains due to their propensity to cause fetal loss rather than birth defects.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virus Zika / Infección por el Virus Zika Límite: Animals / Female / Humans / Male País/Región como asunto: Africa / Asia Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Virus Zika / Infección por el Virus Zika Límite: Animals / Female / Humans / Male País/Región como asunto: Africa / Asia Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido