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A Matter of State: Diversity in Oligodendrocyte Lineage Cells.
Kamen, Yasmine; Pivonkova, Helena; Evans, Kimberley A; Káradóttir, Ragnhildur T.
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  • Kamen Y; Wellcome-Medical Research Council Cambridge Stem Cell Institute & Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
  • Pivonkova H; Wellcome-Medical Research Council Cambridge Stem Cell Institute & Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
  • Evans KA; Wellcome-Medical Research Council Cambridge Stem Cell Institute & Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
  • Káradóttir RT; Wellcome-Medical Research Council Cambridge Stem Cell Institute & Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
Neuroscientist ; 28(2): 144-162, 2022 04.
Article en En | MEDLINE | ID: mdl-33567971
Oligodendrocyte precursor cells (OPCs) give rise to oligodendrocytes which myelinate axons in the central nervous system. Although classically thought to be a homogeneous population, OPCs are reported to have different developmental origins and display regional and temporal diversity in their transcriptome, response to growth factors, and physiological properties. Similarly, evidence is accumulating that myelinating oligodendrocytes display transcriptional heterogeneity. Analyzing this reported heterogeneity suggests that OPCs, and perhaps also myelinating oligodendrocytes, may exist in different functional cell states. Here, we review the evidence indicating that OPCs and oligodendrocytes are diverse, and we discuss the implications of functional OPC states for myelination in the adult brain and for myelin repair.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligodendroglía / Vaina de Mielina Límite: Humans Idioma: En Revista: Neuroscientist Asunto de la revista: NEUROLOGIA / PSIQUIATRIA Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligodendroglía / Vaina de Mielina Límite: Humans Idioma: En Revista: Neuroscientist Asunto de la revista: NEUROLOGIA / PSIQUIATRIA Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos