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Promising nanogels loaded with usnic acid for oral ulcer treatment: development, characterization, and in vivo evaluation in rabbits.
Coskunmeriç, Nesrin; Üstündag Okur, Neslihan; Okur, Mehmet Evren; Ayla, Sule; Yoltas, Aysegül; Karavana, Sinem Yaprak.
Afiliación
  • Coskunmeriç N; Faculty of Pharmacy, Department of Pharmaceutical Technology, Ege University, Bornova, Izmir, Turkey.
  • Üstündag Okur N; Faculty of Pharmacy, Department of Pharmaceutical Technology, University of Health Sciences, Uskudar, Istanbul, Turkey.
  • Okur ME; Faculty of Pharmacy, Department of Pharmacology, University of Health Sciences, Uskudar, Istanbul, Turkey.
  • Ayla S; School of Medicine, Department of Histology and Embryology, Istanbul Medipol University, Beykoz, Istanbul, Turkey.
  • Yoltas A; Faculty of Science, Department of Biology, Fundamental and Industrial Microbiology Division, Ege University, Bornova, Izmir, Turkey.
  • Karavana SY; Faculty of Pharmacy, Department of Pharmaceutical Technology, Ege University, Bornova, Izmir, Turkey.
Pharm Dev Technol ; 26(4): 431-443, 2021 Apr.
Article en En | MEDLINE | ID: mdl-33567946
This study aimed to present an effective formulation targeting oral ulcers that will remain in the application site for a longer period, reducing the frequency of administration. As a candidate formulation, usnic acid (UA) was loaded into the optimum nanogels. The characterization studies included physical, rheological, and bioadhesive properties as well as in vitro release and ex vivo studies. The rheological results revealed that the nanogels present pseudoplastic flow behavior. In vitro drug release showed a prolonged pattern. In further, the chosen UA nanogels showed very low percentages of penetration and permeation. F13, which showed the highest release, suitable bioadhesive properties (0.475 ± 0.033 N/cm2) and eligible particle size (250.22 ± 4.11 nm), PDI (0.089 ± 0.052), and zeta potential (20.56 ± 0.330 mV) values were chosen for in vivo experiments. The selected UA nanogels showed effective antimicrobial activity against Bacillus Cereus and great in vivo wound healing properties. The results indicated that suitable UA nanogels with desired properties could be prepared. The therapeutic potential of the nanogels for oral ulcers was assessed using an animal model and the histopathological findings suggested that the optimized formulation is a good choice for oral ulcer treatment. Nonetheless, further research is recommended to support its efficacy by applying pharmacodynamic and pharmacokinetic studies in human individuals.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cicatrización de Heridas / Benzofuranos / Úlceras Bucales / Nanogeles Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Pharm Dev Technol Asunto de la revista: FARMACIA Año: 2021 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cicatrización de Heridas / Benzofuranos / Úlceras Bucales / Nanogeles Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Pharm Dev Technol Asunto de la revista: FARMACIA Año: 2021 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Reino Unido