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Causal relationships between genetically determined metabolites and human intelligence: a Mendelian randomization study.
Yang, Jian; Zhao, Binbin; Qian, Li; Gao, Fengjie; Fan, Yanjuan; He, Xiaoyan; Ma, Qingyan; Yang, Lihong; Yan, Bin; Wang, Wei; Ma, Xiancang.
Afiliación
  • Yang J; Clinical Research Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
  • Zhao B; Department of Psychiatry, the First Affiliated Hospital of Xi'an Jiaotong University, No. 277 Yanta West Road, Xi'an, 700061, China.
  • Qian L; Department of Psychiatry, the First Affiliated Hospital of Xi'an Jiaotong University, No. 277 Yanta West Road, Xi'an, 700061, China.
  • Gao F; Department of Psychiatry, the First Affiliated Hospital of Xi'an Jiaotong University, No. 277 Yanta West Road, Xi'an, 700061, China.
  • Fan Y; Department of Psychiatry, the First Affiliated Hospital of Xi'an Jiaotong University, No. 277 Yanta West Road, Xi'an, 700061, China.
  • He X; Department of Psychiatry, the First Affiliated Hospital of Xi'an Jiaotong University, No. 277 Yanta West Road, Xi'an, 700061, China.
  • Ma Q; Department of Psychiatry, the First Affiliated Hospital of Xi'an Jiaotong University, No. 277 Yanta West Road, Xi'an, 700061, China.
  • Yang L; Clinical Research Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
  • Yan B; Clinical Research Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
  • Wang W; Department of Psychiatry, the First Affiliated Hospital of Xi'an Jiaotong University, No. 277 Yanta West Road, Xi'an, 700061, China.
  • Ma X; Department of Psychiatry, the First Affiliated Hospital of Xi'an Jiaotong University, No. 277 Yanta West Road, Xi'an, 700061, China. maxiancang@163.com.
Mol Brain ; 14(1): 29, 2021 02 09.
Article en En | MEDLINE | ID: mdl-33563321
Intelligence predicts important life and health outcomes, but the biological mechanisms underlying differences in intelligence are not yet understood. The use of genetically determined metabotypes (GDMs) to understand the role of genetic and environmental factors, and their interactions, in human complex traits has been recently proposed. However, this strategy has not been applied to human intelligence. Here we implemented a two-sample Mendelian randomization (MR) analysis using GDMs to assess the causal relationships between genetically determined metabolites and human intelligence. The standard inverse-variance weighted (IVW) method was used for the primary MR analysis and three additional MR methods (MR-Egger, weighted median, and MR-PRESSO) were used for sensitivity analyses. Using 25 genetic variants as instrumental variables (IVs), our study found that 5-oxoproline was associated with better performance in human intelligence tests (PIVW = 9.25 × 10-5). The causal relationship was robust when sensitivity analyses were applied (PMR-Egger = 0.0001, PWeighted median = 6.29 × 10-6, PMR-PRESSO = 0.0007), and repeated analysis yielded consistent result (PIVW = 0.0087). Similarly, also dihomo-linoleate (20:2n6) and p-acetamidophenylglucuronide showed robust association with intelligence. Our study provides novel insight by integrating genomics and metabolomics to estimate causal effects of genetically determined metabolites on human intelligence, which help to understanding of the biological mechanisms related to human intelligence.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estudio de Asociación del Genoma Completo / Metaboloma / Análisis de la Aleatorización Mendeliana / Inteligencia Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Humans Idioma: En Revista: Mol Brain Asunto de la revista: BIOLOGIA MOLECULAR / CEREBRO Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estudio de Asociación del Genoma Completo / Metaboloma / Análisis de la Aleatorización Mendeliana / Inteligencia Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Humans Idioma: En Revista: Mol Brain Asunto de la revista: BIOLOGIA MOLECULAR / CEREBRO Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido