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Effects of a Rice Bran Dietary Intervention on the Composition of the Intestinal Microbiota of Adults with a High Risk of Colorectal Cancer: A Pilot Randomised-Controlled Trial.
So, Winnie K W; Chan, Judy Y W; Law, Bernard M H; Choi, Kai Chow; Ching, Jessica Y L; Chan, Kam Leung; Tang, Raymond S Y; Chan, Carmen W H; Wu, Justin C Y; Tsui, Stephen K W.
Afiliación
  • So WKW; The Nethersole School of Nursing, The Chinese University of Hong Kong, Hong Kong, China.
  • Chan JYW; The Nethersole School of Nursing, The Chinese University of Hong Kong, Hong Kong, China.
  • Law BMH; The Nethersole School of Nursing, The Chinese University of Hong Kong, Hong Kong, China.
  • Choi KC; The Nethersole School of Nursing, The Chinese University of Hong Kong, Hong Kong, China.
  • Ching JYL; School of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong, China.
  • Chan KL; Hong Kong Institute of Integrative Medicine, The Chinese University of Hong Kong, Hong Kong, China.
  • Tang RSY; Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China.
  • Chan CWH; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
  • Wu JCY; School of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong, China.
  • Tsui SKW; Hong Kong Institute of Integrative Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Nutrients ; 13(2)2021 Feb 06.
Article en En | MEDLINE | ID: mdl-33561964
Rice bran exhibits chemopreventive properties that may help to prevent colorectal cancer (CRC), and a short-term rice bran dietary intervention may promote intestinal health via modification of the intestinal microbiota. We conducted a pilot, double-blind, randomised placebo-controlled trial to assess the feasibility of implementing a long-term (24-week) rice bran dietary intervention in Chinese subjects with a high risk of CRC, and to examine its effects on the composition of their intestinal microbiota. Forty subjects were randomised into the intervention group (n = 19) or the control group (n = 20). The intervention participants consumed 30 g of rice bran over 24-h intervals for 24 weeks, whilst the control participants consumed 30 g of rice powder on the same schedule. High rates of retention (97.5%) and compliance (≥91.3%) were observed. No adverse effects were reported. The intervention significantly enhanced the intestinal abundance of Firmicutes and Lactobacillus, and tended to increase the Firmicutes/Bacteroidetes ratio and the intestinal abundance of Prevotella_9 and the health-promoting Lactobacillales and Bifidobacteria, but had no effect on bacterial diversity. Overall, a 24-week rice bran dietary intervention was feasible, and may increase intestinal health by inducing health-promoting modification of the intestinal microbiota. Further larger-scale studies involving a longer intervention duration and multiple follow-up outcome assessments are recommended.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oryza / Fibras de la Dieta / Neoplasias Colorrectales / Microbioma Gastrointestinal / Dieta Saludable Tipo de estudio: Clinical_trials / Etiology_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Nutrients Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oryza / Fibras de la Dieta / Neoplasias Colorrectales / Microbioma Gastrointestinal / Dieta Saludable Tipo de estudio: Clinical_trials / Etiology_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Nutrients Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza