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The study of 9,10-dihydroacridine derivatives as a new and effective molecular scaffold for antibacterial agent development.
Chen, Cui-Cui; Zhang, Yi-Qi; Zhong, Dong-Xiao; Huang, Xuan-He; Zhang, Yi-Han; Jiang, Wen-Hao; Li, Ming; Chen, Qian; Wong, Wing-Leung; Lu, Yu-Jing.
Afiliación
  • Chen CC; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, PR China.
  • Zhang YQ; College of Marine Science, Shandong University, Weihai, 264209, PR China.
  • Zhong DX; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, PR China.
  • Huang XH; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, PR China.
  • Zhang YH; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, PR China.
  • Jiang WH; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, PR China.
  • Li M; The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510700, PR China.
  • Chen Q; School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, 510006, PR China. Electronic address: qianchen@gdut.edu.cn.
  • Wong WL; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, 529020, PR China. Electronic address: wleungwong@outlook.com.
  • Lu YJ; School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, PR China. Electronic address: luyj@gdut.edu.cn.
Biochem Biophys Res Commun ; 546: 40-45, 2021 03 26.
Article en En | MEDLINE | ID: mdl-33561747
The emergence of worldwide spreading drug-resistant bacteria has been a serious threat to public health during the past decades. The development of new and effective antibacterial agents to address this critical issue is an urgent action. In the present study, we investigated the antibacterial activity of two 9,10-dihydroacridine derivatives and their mechanism. Both compounds were found possessing strong antibacterial activity against some selected Gram-positive bacteria including MRSA, VISA and VRE. The biological study suggests that the compounds promoted FtsZ polymerization and also disrupted Z-ring formation at the dividing site and consequently, the bacterial cell division is interrupted and causing cell death.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Acridinas / Diseño de Fármacos / Antibacterianos Idioma: En Revista: Biochem Biophys Res Commun Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Acridinas / Diseño de Fármacos / Antibacterianos Idioma: En Revista: Biochem Biophys Res Commun Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos