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Characteristics of T- and NK-cell Lymphomas After Renal Transplantation: A French National Multicentric Cohort Study.
Barba, Thomas; Bachy, Emmanuel; Maarek, Alizée; Fossard, Gaëlle; Genestier, Laurent; Anglicheau, Dany; Moal, Valérie; Dantal, Jacques; Rieu, Philippe; Chemouny, Jonathan; Charrier, Manon; Durrbach, Antoine; Provot, François; Ducloux, Didier; Westeel, Pierre-François; Heng, Anne-Elisabeth; Rerolle, Jean-Philippe; Barrou, Benoit; Grimbert, Philippe; Chatelet, Valérie; Mousson, Christiane; Janbon, Bénédicte; Pernin, Vincent; Frimat, Luc; Ouali, Nacera; Glotz, Denis; Thierry, Antoine; Mariat, Christophe; Büchler, Mathias; Gaulard, Philippe; Leblond, Véronique; Morelon, Emmanuel; Dubois, Valérie; Salles, Gilles; Caillard, Sophie; Thaunat, Olivier.
Afiliación
  • Barba T; CIRI, INSERM U1111, Lyon, France.
  • Bachy E; Department of Hematology, HCL Centre Hospitalier Lyon Sud, Université de Lyon, Lyon, France.
  • Maarek A; CRCL, INSERM U1052, Pierre-Bénite, France.
  • Fossard G; Department of Transplantation, Nephrology and Clinical Immunology, HCL Hôpital Edouard Herriot, Université de Lyon, Lyon, France.
  • Genestier L; Department of Hematology, HCL Centre Hospitalier Lyon Sud, Université de Lyon, Lyon, France.
  • Anglicheau D; CRCL, INSERM U1052, Pierre-Bénite, France.
  • Moal V; French PTLD Registry, University Hospital of Strasbourg, Strasbourg, France.
  • Dantal J; Renal Transplantation Department, Assistance Publique-Hôpitaux de Paris (AP-HP), Necker Hospital, Paris, France.
  • Rieu P; French PTLD Registry, University Hospital of Strasbourg, Strasbourg, France.
  • Chemouny J; Department of Nephrology, AP-HM Hôpital de la Conception, Marseille, France.
  • Charrier M; French PTLD Registry, University Hospital of Strasbourg, Strasbourg, France.
  • Durrbach A; Department of Nephrology and Transplantation, Hôpital Hôtel Dieu, Nantes, France.
  • Provot F; French PTLD Registry, University Hospital of Strasbourg, Strasbourg, France.
  • Ducloux D; Transplant Unit, Nephrology Department, University Hospital, Reims, France.
  • Westeel PF; French PTLD Registry, University Hospital of Strasbourg, Strasbourg, France.
  • Heng AE; Transplant Unit, Department of Nephrology, University Hospital, Rennes, France.
  • Rerolle JP; French PTLD Registry, University Hospital of Strasbourg, Strasbourg, France.
  • Barrou B; Department of Nephrology, Transplantation, Dialysis and Apheresis, Bordeaux University Hospital, Bordeaux, France.
  • Grimbert P; French PTLD Registry, University Hospital of Strasbourg, Strasbourg, France.
  • Chatelet V; Department of Nephrology and Transplantation, Assistance Publique-Hôpitaux de Paris (AP-HP), Le Kremlin Bicetre, France.
  • Mousson C; French PTLD Registry, University Hospital of Strasbourg, Strasbourg, France.
  • Janbon B; Transplant Unit, Nephrology Department, University Hospital, Lille, France.
  • Pernin V; French PTLD Registry, University Hospital of Strasbourg, Strasbourg, France.
  • Frimat L; Transplant Unit, Nephrology Department, Besançon University Hospital, Besançon, France.
  • Ouali N; French PTLD Registry, University Hospital of Strasbourg, Strasbourg, France.
  • Glotz D; Transplant Unit, Nephrology Department, University Hospital, Amiens, France.
  • Thierry A; French PTLD Registry, University Hospital of Strasbourg, Strasbourg, France.
  • Mariat C; Nephrology Department, CHU Clermont-Ferrand, Clermont-Ferrand, France.
  • Büchler M; French PTLD Registry, University Hospital of Strasbourg, Strasbourg, France.
  • Gaulard P; Department of Nephrology, Dupuytren Hospital, Limoges, France.
  • Leblond V; French PTLD Registry, University Hospital of Strasbourg, Strasbourg, France.
  • Morelon E; Department of Urology, Nephrology and Transplantation, Assistance Publique-Hôpitaux de Paris (AP-HP), Pitié-Salpêtrière Hospital, Paris, France.
  • Dubois V; French PTLD Registry, University Hospital of Strasbourg, Strasbourg, France.
  • Salles G; Department of Nephrology and Renal Transplantation, Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier Henri-Mondor, Créteil, France.
  • Caillard S; French PTLD Registry, University Hospital of Strasbourg, Strasbourg, France.
  • Thaunat O; Nephrology Department, CHU de Caen, Caen, France.
Transplantation ; 105(8): 1858-1868, 2021 08 01.
Article en En | MEDLINE | ID: mdl-33560724
BACKGROUND: Posttransplant lymphoproliferative disorders (PTLDs) encompass a spectrum of heterogeneous entities. Because the vast majority of cases PTLD arise from B cells, available data on PTLD of T or NK phenotype (T/NK-cell PTLD) are scarce, which limits the quality of the management of these patients. METHODS: All adult cases of PTLD diagnosed in France were prospectively recorded in the national registry between 1998 and 2007. Crosschecking the registry data with 2 other independent national databases identified 58 cases of T/NK-cell PTLD. This cohort was then compared with (i) the 395 cases of B-cell PTLD from the registry, and of (ii) a cohort of 148 T/NK-cell lymphomas diagnosed in nontransplanted patients. RESULTS: T/NK-cell PTLD occurred significantly later after transplantation and had a worse overall survival than B-cell PTLD. Two subtypes of T/NK-cell PTLD were distinguished: (i) cutaneous (28%) and (ii) systemic (72%), the latter being associated with a worse prognosis. Compared with T/NK-cell lymphomas of nontransplanted patients, overall survival of systemic T/NK-cell PTLD was worse (hazard ratio: 2.64 [1.76-3.94]; P < 0.00001). CONCLUSIONS: This difference, which persisted after adjustment on tumoral mass, histological subtype, and extension of the disease at diagnosis could be explained by the fact that transplanted patients were less intensively treated and responded less to chemotherapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfoma de Células T / Trasplante de Riñón Tipo de estudio: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Transplantation Año: 2021 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfoma de Células T / Trasplante de Riñón Tipo de estudio: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Transplantation Año: 2021 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos