Your browser doesn't support javascript.
loading
Differential Mitochondrial Gene Expression in Adipose Tissue Following Weight Loss Induced by Diet or Bariatric Surgery.
van der Kolk, Birgitta W; Muniandy, Maheswary; Kaminska, Dorota; Alvarez, Marcus; Ko, Arthur; Miao, Zong; Valsesia, Armand; Langin, Dominique; Vaittinen, Maija; Pääkkönen, Mirva; Jokinen, Riikka; Kaye, Sanna; Heinonen, Sini; Virtanen, Kirsi A; Andersson, Daniel P; Männistö, Ville; Saris, Wim H; Astrup, Arne; Rydén, Mikael; Blaak, Ellen E; Pajukanta, Päivi; Pihlajamäki, Jussi; Pietiläinen, Kirsi H.
Afiliación
  • van der Kolk BW; Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Finland.
  • Muniandy M; Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Finland.
  • Kaminska D; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
  • Alvarez M; Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
  • Ko A; Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
  • Miao Z; Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
  • Valsesia A; Bioinformatics Interdepartmental Program, UCLA, Los Angeles, CA, USA.
  • Langin D; Nestlé Institute of Health Sciences, 1015 Lausanne, Switzerland.
  • Vaittinen M; Institut National de la Santé et de la Recherche Médicale (Inserm), Université Paul Sabatier, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France.
  • Pääkkönen M; Department of Biochemistry, Toulouse University Hospitals, France.
  • Jokinen R; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
  • Kaye S; Turku Bioscience Centre, University of Turku and Åbo Akademi University, Finland.
  • Heinonen S; Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Finland.
  • Virtanen KA; Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Finland.
  • Andersson DP; Obesity Research Unit, Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Finland.
  • Männistö V; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
  • Saris WH; Department of Medicine, Endocrinology and Clinical Nutrition, Kuopio University Hospital, Kuopio, Finland.
  • Astrup A; Turku PET Center, Turku University Hospital, Turku, Finland.
  • Rydén M; Department of Medicine (H7), Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden.
  • Blaak EE; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
  • Pajukanta P; Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, MD Maastricht, The Netherlands.
  • Pihlajamäki J; Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
  • Pietiläinen KH; Department of Medicine (H7), Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden.
J Clin Endocrinol Metab ; 106(5): 1312-1324, 2021 04 23.
Article en En | MEDLINE | ID: mdl-33560372
CONTEXT: Mitochondria are essential for cellular energy homeostasis, yet their role in subcutaneous adipose tissue (SAT) during different types of weight-loss interventions remains unknown. OBJECTIVE: To investigate how SAT mitochondria change following diet-induced and bariatric surgery-induced weight-loss interventions in 4 independent weight-loss studies. METHODS: The DiOGenes study is a European multicenter dietary intervention with an 8-week low caloric diet (LCD; 800 kcal/d; n = 261) and 6-month weight-maintenance (n = 121) period. The Kuopio Obesity Surgery study (KOBS) is a Roux-en-Y gastric bypass (RYGB) surgery study (n = 172) with a 1-year follow-up. We associated weight-loss percentage with global and 2210 mitochondria-related RNA transcripts in linear regression analysis adjusted for age and sex. We repeated these analyses in 2 studies. The Finnish CRYO study has a 6-week LCD (800-1000 kcal/d; n = 19) and a 10.5-month follow-up. The Swedish DEOSH study is a RYGB surgery study with a 2-year (n = 49) and 5-year (n = 37) follow-up. RESULTS: Diet-induced weight loss led to a significant transcriptional downregulation of oxidative phosphorylation (DiOGenes; ingenuity pathway analysis [IPA] z-scores: -8.7 following LCD, -4.4 following weight maintenance; CRYO: IPA z-score: -5.6, all P < 0.001), while upregulation followed surgery-induced weight loss (KOBS: IPA z-score: 1.8, P < 0.001; in DEOSH: IPA z-scores: 4.0 following 2 years, 0.0 following 5 years). We confirmed an upregulated oxidative phosphorylation at the proteomics level following surgery (IPA z-score: 3.2, P < 0.001). CONCLUSIONS: Differentially regulated SAT mitochondria-related gene expressions suggest qualitative alterations between weight-loss interventions, providing insights into the potential molecular mechanistic targets for weight-loss success.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pérdida de Peso / Tejido Adiposo / Genes Mitocondriales Tipo de estudio: Observational_studies / Qualitative_research / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Clin Endocrinol Metab Año: 2021 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pérdida de Peso / Tejido Adiposo / Genes Mitocondriales Tipo de estudio: Observational_studies / Qualitative_research / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Clin Endocrinol Metab Año: 2021 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Estados Unidos