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Natural Products as Potential Agents against SARS-CoV and SARSCoV- 2.
Raimundo E Silva, Joanda Paolla; Acevedo, Chonny Alexander Herrera; de Souza, Thalisson Amorim; de Menezes, Renata Priscila Barros; Sessions, Zoe L; Abreu, Lucas Silva; Cibulski, Samuel Paulo; Scotti, Luciana; da Silva, Marcelo Sobral; Muratov, Eugene N; Scotti, Marcus Tullius; Tavares, Josean Fechine.
Afiliación
  • Raimundo E Silva JP; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraiba, Joso Pessoa, Brazil.
  • Acevedo CAH; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraiba, Joso Pessoa, Brazil.
  • de Souza TA; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraiba, Joso Pessoa, Brazil.
  • de Menezes RPB; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraiba, Joso Pessoa, Brazil.
  • Sessions ZL; Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, 27599, United States.
  • Abreu LS; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraiba, Joso Pessoa, Brazil.
  • Cibulski SP; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraiba, Joso Pessoa, Brazil.
  • Scotti L; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraiba, Joso Pessoa, Brazil.
  • da Silva MS; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraiba, Joso Pessoa, Brazil.
  • Muratov EN; Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, 27599, United States.
  • Scotti MT; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraiba, Joso Pessoa, Brazil.
  • Tavares JF; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraiba, Joso Pessoa, Brazil.
Curr Med Chem ; 28(27): 5498-5526, 2021.
Article en En | MEDLINE | ID: mdl-33550959
BACKGROUND: Natural products are useful agents for the discovery of new lead- compounds and effective drugs to combat coronaviruses (CoV). OBJECTIVE: The present work provides an overview of natural substances, plant extracts, and essential oils as potential anti-SARS-CoV agents. In addition, this work evaluates their drug-like properties which are essential in the selection of compounds in order to accelerate the drug development process. METHODS: The search was carried out using PubMed, ScienceDirect and SciFinder. Articles addressing plant-based natural products as potential SARS-CoV or SARS-CoV-2 agents within the last seventeen years were analyzed and selected. The descriptors for Chemometrics analysis were obtained in alvaDesc and the principal component analysis (PCA) was carried out in SIMCA version 13.0. RESULTS: Based on in vitro assays and computational analyses, this review covers twentynine medicinal plant species and more than 300 isolated substances as potential anti-coronavirus agents. Among them, flavonoids and terpenes are the most promising compound classes. In silico analyses of drug-like properties corroborate these findings and indicate promising candidates for in vitro and in vivo studies to validate their activity. CONCLUSION: This paper highlights the role of ethnopharmacology in drug discovery and suggests the use of integrative (in silico/ in vitro) and chemocentric approaches to strengthen current studies and guide future research in the field of antiviral agents.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plantas Medicinales / Productos Biológicos / COVID-19 Límite: Humans Idioma: En Revista: Curr Med Chem Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Emiratos Árabes Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plantas Medicinales / Productos Biológicos / COVID-19 Límite: Humans Idioma: En Revista: Curr Med Chem Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Emiratos Árabes Unidos