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Noninvasive assessment of liver fibrosis by dual-layer spectral detector CT.
Morita, Koichiro; Nishie, Akihiro; Ushijima, Yasuhiro; Takayama, Yukihisa; Fujita, Nobuhiro; Kubo, Yuichiro; Ishimatsu, Keisuke; Yoshizumi, Tomoharu; Maehara, Junki; Ishigami, Kousei.
Afiliación
  • Morita K; Departments of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address: morita-k@med.kyushu-u.ac.jp.
  • Nishie A; Departments of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address: anishie@radiol.med.kyushu-u.ac.jp.
  • Ushijima Y; Departments of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address: ushijima@radiol.med.kyushu-u.ac.jp.
  • Takayama Y; Departments of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address: ytaka@radiol.med.kyushu-u.ac.jp.
  • Fujita N; Departments of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address: n-fujita@radiol.med.kyushu-u.ac.jp.
  • Kubo Y; Departments of Molecular Imaging & Diagnosis, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address: yukubo@med.kyushu-u.ac.jp.
  • Ishimatsu K; Departments of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address: kishim@radiol.med.kyushu-u.ac.jp.
  • Yoshizumi T; Departments of Surgery and Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address: yosizumi@surg2.med.kyushu-u.ac.jp.
  • Maehara J; Departments of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address: j-mae@med.kyushu-u.ac.jp.
  • Ishigami K; Departments of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address: ishigami@radiol.med.kyushu-u.ac.jp.
Eur J Radiol ; 136: 109575, 2021 Mar.
Article en En | MEDLINE | ID: mdl-33548853
PURPOSE: To elucidate the diagnostic ability of liver fibrosis using (1) liver parenchymal iodine density on equilibrium computed tomographic imaging and (2) extracellular volume (ECV) measured by dual-layer spectral detector CT. METHODS: From April 2018 to June 2019, 68 patients [mean age, 62 years; 39 males, 29 females] underwent dynamic contrast-enhanced CT by a dual-layer spectral detector CT system before liver transplantation or liver resection. The iodine densities of liver parenchyma (I liver) and aorta (I aorta) were independently measured by two radiologists at the equilibrium phase. The iodine-density ratio (I-ratio) (I liver/ I aorta) and the CT-ECV were calculated. Spearman's rank correlation coefficient was used to analyze the relationship between the I-ratio or the CT-ECV and the fibrosis stage. A receiver operating characteristic (ROC) curve analysis was performed to determine the accuracy of the I-ratio and the CT-ECV for discriminating fibrosis stages. RESULTS: For both readers, the I-ratio and the CT-ECV increased significantly as the fibrosis stage advanced (I-ratio: rho = 0.380 and 0.443, p < 0.01; CT-ECV: rho = 0.423 and 0.469, p < 0.01). The CT-ECV showed better diagnostic accuracy for staging fibrosis, and the area under the ROC curve values for discriminating F4 stage were 0.884 and 0.925. The two readers' cutoff values of the CT-ECV for diagnosing fibrosis as F4 were 26.2 % and 29.3 %, with 95.0 % and 90.0 % sensitivity and 72.9 % and 85.4 % specificity, respectively. CONCLUSION: The liver parenchymal iodine density on the equilibrium phase and the CT-ECV can be useful for predicting a high stage of liver fibrosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Yodo / Cirrosis Hepática Tipo de estudio: Prognostic_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Radiol Año: 2021 Tipo del documento: Article Pais de publicación: Irlanda
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Yodo / Cirrosis Hepática Tipo de estudio: Prognostic_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Radiol Año: 2021 Tipo del documento: Article Pais de publicación: Irlanda