Advances in understanding immune mechanisms of food protein-induced enterocolitis syndrome.
Ann Allergy Asthma Immunol
; 126(5): 478-481, 2021 05.
Article
en En
| MEDLINE
| ID: mdl-33548465
OBJECTIVE: This review provides an overview of our current understanding of the mechanisms of food protein-induced enterocolitis syndrome (FPIES). DATA SOURCES: To capture recent articles published since our previous comprehensive review on the pathophysiology of FPIES, we performed a literature search through PubMed database, using the search terms FPIES and food protein-induced enterocolitis syndrome from 2016 to the current year. STUDY SELECTIONS: Studies in English containing biomarker or immune data were reviewed and summarized. RESULTS: Studies of peripheral blood fail to exhibit evidence of antigen-specific humoral or cellular immunity underlying clinical reactivity to foods in FPIES. However, growing evidence suggests a robust systemic innate immune activation occurring during FPIES reactions and the activation of neuroendocrine pathways. CONCLUSION: FPIES reactions are associated with marked activation of innate immune and neuroendocrine pathways; however, the mechanism underlying the specific recognition of foods remains elusive.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas en la Dieta
/
Enterocolitis
/
Hipersensibilidad a los Alimentos
/
Inmunidad Celular
/
Inmunidad Innata
Límite:
Humans
Idioma:
En
Revista:
Ann Allergy Asthma Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2021
Tipo del documento:
Article
Pais de publicación:
Estados Unidos