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Neurological Sequelae in Patients with COVID-19: A Histopathological Perspective.
Fisicaro, Francesco; Di Napoli, Mario; Liberto, Aldo; Fanella, Martina; Di Stasio, Flavio; Pennisi, Manuela; Bella, Rita; Lanza, Giuseppe; Mansueto, Gelsomina.
Afiliación
  • Fisicaro F; Department of Biomedical and Biotechnological Sciences, University of Catania, Via Santa Sofia 97, 95123 Catania, Italy.
  • Di Napoli M; Department of Neurology and Stroke Unit, San Camillo de' Lellis General Hospital, Viale Kennedy 1, 02100 Rieti, Italy.
  • Liberto A; Department of Biomedical and Biotechnological Sciences, University of Catania, Via Santa Sofia 97, 95123 Catania, Italy.
  • Fanella M; Department of Neurology and Stroke Unit, San Camillo de' Lellis General Hospital, Viale Kennedy 1, 02100 Rieti, Italy.
  • Di Stasio F; Department of Neurology and Stroke Unit Cesena-Forlì, Bufalini Hospital, AUSL Romagna, Viale Ghirotti 286, 47521 Cesena, Italy.
  • Pennisi M; Department of Biomedical and Biotechnological Sciences, University of Catania, Via Santa Sofia 97, 95123 Catania, Italy.
  • Bella R; Department of Medical and Surgical Sciences and Advanced Technologies, University of Catania, Via Santa Sofia 87, 95123 Catania, Italy.
  • Lanza G; Department of Surgery and Medical-Surgery Specialties, University of Catania, Via Santa Sofia 78, 95123 Catania, Italy.
  • Mansueto G; Department of Neurology IC, Oasi Research Institute-IRCCS, Via Conte Ruggero 78, 94018 Troina, Italy.
Int J Environ Res Public Health ; 18(4)2021 02 03.
Article en En | MEDLINE | ID: mdl-33546463
BACKGROUND: Neuroinvasive properties of SARS-CoV-2 have allowed the hypothesis of several pathogenic mechanisms related to acute and chronic neurological sequelae. However, neuropathological correlates have been poorly systematically investigated, being retrieved from reports of single case or limited case series still. METHODS: A PubMed search was carried out to review all publications on autopsy in subjects with "COronaVIrus Disease-19" (COVID-19). Among them, we focused on histological findings of the brain, which were compared with those from the authors' autoptic studies performed in some COVID-19 patients. RESULTS: Only seven studies reported histological evidence of brain pathology in patients deceased for COVID-19, including three with reverse transcription-quantitative polymerase chain reaction evidence of viral infection. All these studies, in line with our experience, showed vascular-related and infection-related secondary inflammatory tissue damage due to an abnormal immune response. It is still unclear, however, whether these findings are the effect of a direct viral pathology or rather reflect a non-specific consequence of cardiovascular and pulmonary disease on the brain. CONCLUSIONS: Notwithstanding the limited evidence available and the heterogeneity of the studies, we provide a preliminary description of the relationship between SARS-CoV-2 and brain sequelae. Systematic autoptic investigations are needed for accurate detection and adequate management of these patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / COVID-19 / Enfermedades del Sistema Nervioso Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Int J Environ Res Public Health Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / COVID-19 / Enfermedades del Sistema Nervioso Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Int J Environ Res Public Health Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza