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Brazilian Aedes aegypti as a Competent Vector for Multiple Complex Arboviral Coinfections.
Rodrigues, Nilton Barnabé; Godoy, Raquel Soares Maia; Orfano, Alessandra Silva; Chaves, Barbara Aparecida; Campolina, Thais Bonifácio; Costa, Breno Dos Anjos; Félix, Luíza Dos Santos; Silva, Breno Melo; Norris, Douglas Eric; Pimenta, Paulo Filemon Paolucci; Secundino, Nagila Francinete Costa.
Afiliación
  • Rodrigues NB; Laboratory of Medical Entomology, René Rachou Institute-FIOCRUZ-Minas, Belo Horizonte, Minas Gerais, Brazil.
  • Godoy RSM; Laboratory of Medical Entomology, René Rachou Institute-FIOCRUZ-Minas, Belo Horizonte, Minas Gerais, Brazil.
  • Orfano AS; Laboratory of Medical Entomology, René Rachou Institute-FIOCRUZ-Minas, Belo Horizonte, Minas Gerais, Brazil.
  • Chaves BA; Instituto de Pesquisas Clínicas Carlos Borborema, Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Amazonas, Brazil.
  • Campolina TB; Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, Amazonas, Brazil.
  • Costa BDA; Laboratory of Medical Entomology, René Rachou Institute-FIOCRUZ-Minas, Belo Horizonte, Minas Gerais, Brazil.
  • Félix LDS; Laboratory of Medical Entomology, René Rachou Institute-FIOCRUZ-Minas, Belo Horizonte, Minas Gerais, Brazil.
  • Silva BM; Laboratory of Medical Entomology, René Rachou Institute-FIOCRUZ-Minas, Belo Horizonte, Minas Gerais, Brazil.
  • Norris DE; Department of Biological Sciences, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, Brazil.
  • Pimenta PFP; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
  • Secundino NFC; Laboratory of Medical Entomology, René Rachou Institute-FIOCRUZ-Minas, Belo Horizonte, Minas Gerais, Brazil.
J Infect Dis ; 224(1): 101-108, 2021 07 02.
Article en En | MEDLINE | ID: mdl-33544850
BACKGROUND: Aedes aegypti is a highly competent vector in the transmission of arboviruses, such as chikungunya, dengue, Zika, and yellow fever viruses, and causes single and coinfections in the populations of tropical countries. METHODS: The infection rate, viral abundance (VA), vector competence (VC), disseminated infection, and survival rate were recorded after single and multiple infections of the vector with 15 combinations of chikungunya, dengue, Zika, and yellow fever arboviruses. RESULTS: Infection rates were 100% in all single and multiple infection experiments, except in 1 triple coinfection that presented a rate of 50%. The VC and disseminated infection rate varied from 100% (in single and quadruple infections) to 40% (in dual and triple infections). The dual and triple coinfections altered the VC and/or VA of ≥1 arbovirus. The highest viral VAs were detected for a single infection with chikungunya. The VAs in quadruple infections were similar when compared with each respective single infection. A decrease in survival rates was observed in a few combinations. CONCLUSIONS: A. aegypti was able to host all single and multiple arboviral coinfections. The interference of the chikungunya virus suggests that distinct arbovirus families may have a significant role in complex coinfections.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por Arbovirus / Aedes / Coinfección / Mosquitos Vectores Límite: Animals País/Región como asunto: America do sul / Brasil Idioma: En Revista: J Infect Dis Año: 2021 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por Arbovirus / Aedes / Coinfección / Mosquitos Vectores Límite: Animals País/Región como asunto: America do sul / Brasil Idioma: En Revista: J Infect Dis Año: 2021 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos