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Striped occipital cortex and intragyral hemorrhage: Novel magnetic resonance imaging markers for cerebral amyloid angiopathy.
Koemans, E A; Voigt, S; Rasing, I; Jolink, Wmt; van Harten, T W; van der Grond, J; van Rooden, S; Schreuder, Fhbm; Freeze, W M; van Buchem, M A; van Zwet, E W; van Veluw, S J; Terwindt, G M; van Osch, Mjp; Klijn, Cjm; van Walderveen, Maa; Wermer, Mjh.
Afiliación
  • Koemans EA; Department of Neurology, 4501Leiden University Medical Center, Leiden, the Netherlands.
  • Voigt S; Department of Neurology, 4501Leiden University Medical Center, Leiden, the Netherlands.
  • Rasing I; Department of Neurology, 4501Leiden University Medical Center, Leiden, the Netherlands.
  • Jolink W; Department of Neurology and Neurosurgery, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, the Netherlands.
  • van Harten TW; Department of Radiology, 4501Leiden University Medical Center, Leiden, the Netherlands.
  • van der Grond J; Department of Radiology, 4501Leiden University Medical Center, Leiden, the Netherlands.
  • van Rooden S; Department of Radiology, 4501Leiden University Medical Center, Leiden, the Netherlands.
  • Schreuder F; Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.
  • Freeze WM; Department of Radiology, 4501Leiden University Medical Center, Leiden, the Netherlands.
  • van Buchem MA; Department of Radiology, 4501Leiden University Medical Center, Leiden, the Netherlands.
  • van Zwet EW; Department of Biomedical Data Sciences, 4501Leiden University Medical Center, Leiden, the Netherlands.
  • van Veluw SJ; Department of Radiology, 4501Leiden University Medical Center, Leiden, the Netherlands.
  • Terwindt GM; Department of Neurology, 4501Leiden University Medical Center, Leiden, the Netherlands.
  • van Osch M; Department of Radiology, 4501Leiden University Medical Center, Leiden, the Netherlands.
  • Klijn C; Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.
  • van Walderveen M; Department of Radiology, 4501Leiden University Medical Center, Leiden, the Netherlands.
  • Wermer M; Department of Neurology, 4501Leiden University Medical Center, Leiden, the Netherlands.
Int J Stroke ; 16(9): 1031-1038, 2021 12.
Article en En | MEDLINE | ID: mdl-33535905
BACKGROUND AND AIM: To investigate whether a striped occipital cortex and intragyral hemorrhage, two markers recently detected on ultra-high-field 7-tesla-magnetic resonance imaging in hereditary cerebral amyloid angiopathy (CAA), also occur in sporadic CAA (sCAA) or non-sCAA intracerebral hemorrhage (ICH). METHODS: We performed 7-tesla-magnetic resonance imaging in patients with probable sCAA and patients with non-sCAA-ICH. Striped occipital cortex (linear hypointense stripes perpendicular to the cortex) and intragyral hemorrhage (hemorrhage restricted to the juxtacortical white matter of one gyrus) were scored on T2*-weighted magnetic resonance imaging. We assessed the association between the markers, other CAA-magnetic resonance imaging markers and clinical features. RESULTS: We included 33 patients with sCAA (median age 70 years) and 29 patients with non-sCAA-ICH (median age 58 years). Striped occipital cortex was detected in one (3%) patient with severe sCAA. Five intragyral hemorrhages were found in four (12%) sCAA patients. The markers were absent in the non-sCAA-ICH group. Patients with intragyral hemorrhages had more lobar ICHs (median count 6.5 vs. 1.0), lobar microbleeds (median count >50 vs. 15), and lower median cognitive scores (Mini Mental State Exam: 20 vs. 28, Montreal Cognitive Assessment: 18 vs. 24) compared with patients with sCAA without intragyral hemorrhage. In 12 (36%) patients, sCAA diagnosis was changed to mixed-type small vessel disease due to deep bleeds previously unobserved on lower field-magnetic resonance imaging. CONCLUSION: Whereas a striped occipital cortex is rare in sCAA, 12% of patients with sCAA have intragyral hemorrhages. Intragyral hemorrhages seem to be related to advanced disease and their absence in patients with non-sCAA-ICH could suggest specificity for CAA.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Angiopatía Amiloide Cerebral / Accidente Cerebrovascular Límite: Aged / Humans / Middle aged Idioma: En Revista: Int J Stroke Año: 2021 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Angiopatía Amiloide Cerebral / Accidente Cerebrovascular Límite: Aged / Humans / Middle aged Idioma: En Revista: Int J Stroke Año: 2021 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos