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Clinical outcomes of isolated deep grey matter infarcts after endovascular treatment of large vessel occlusion stroke.
Ospel, Johanna; Mayank, Arnuv; Qiu, Wu; Almekhlafi, Mohammed; Menon, Bijoy; McTaggart, Ryan; Nogueira, Raul; Demchuk, Andrew; Joshi, Manish; Zerna, Charlotte; Chapot, Rene; Bharatha, Aditya; Jadhav, Ashutosh; Nagel, Simon; Poppe, Alexandre; Tymianski, Michael; Hill, Michael; Goyal, Mayank.
Afiliación
  • Ospel J; Clinical Neurosciences, Foothills Medical Centre, University of Calgary, 1403 29th St. NW, Calgary, AB, T2N2T9, Canada.
  • Mayank A; Radiology, University Hospital of Basel, Basel, Switzerland.
  • Qiu W; Clinical Neurosciences, Foothills Medical Centre, University of Calgary, 1403 29th St. NW, Calgary, AB, T2N2T9, Canada.
  • Almekhlafi M; Clinical Neurosciences, Foothills Medical Centre, University of Calgary, 1403 29th St. NW, Calgary, AB, T2N2T9, Canada.
  • Menon B; Clinical Neurosciences, Foothills Medical Centre, University of Calgary, 1403 29th St. NW, Calgary, AB, T2N2T9, Canada.
  • McTaggart R; Radiology, Foothills Medical Centre, University of Calgary, 1403 29th St. NW, Calgary, AB, T2N2T9, Canada.
  • Nogueira R; Clinical Neurosciences, Foothills Medical Centre, University of Calgary, 1403 29th St. NW, Calgary, AB, T2N2T9, Canada.
  • Demchuk A; Radiology, Foothills Medical Centre, University of Calgary, 1403 29th St. NW, Calgary, AB, T2N2T9, Canada.
  • Joshi M; Interventional Radiology, Warren Alpert Medical School of Brown University, Providence, RI, USA.
  • Zerna C; Neurology, Emory University School of Medicine, Atlanta, GA, USA.
  • Chapot R; Clinical Neurosciences, Foothills Medical Centre, University of Calgary, 1403 29th St. NW, Calgary, AB, T2N2T9, Canada.
  • Bharatha A; Radiology, Foothills Medical Centre, University of Calgary, 1403 29th St. NW, Calgary, AB, T2N2T9, Canada.
  • Jadhav A; Clinical Neurosciences, Foothills Medical Centre, University of Calgary, 1403 29th St. NW, Calgary, AB, T2N2T9, Canada.
  • Nagel S; Radiology, Foothills Medical Centre, University of Calgary, 1403 29th St. NW, Calgary, AB, T2N2T9, Canada.
  • Poppe A; Clinical Neurosciences, Foothills Medical Centre, University of Calgary, 1403 29th St. NW, Calgary, AB, T2N2T9, Canada.
  • Tymianski M; Neuroradiology, Alfred Krupp Krankenhaus Essen, Essen, Germany.
  • Hill M; St. Michael's Hospital, Toronto, Canada.
  • Goyal M; University of Pittsburgh, Pittsburgh, USA.
Neuroradiology ; 63(9): 1463-1469, 2021 Sep.
Article en En | MEDLINE | ID: mdl-33528624
PURPOSE: There are few data on the prevalence and impact of isolated deep grey matter infarction in acute stroke. In this study, we aimed to investigate the prevalence of isolated deep grey matter infarcts and their impact on the outcome. METHODS: Infarcts on 24-h follow-up imaging (non-contrast head CT or diffusion-weighted MRI) in the ESCAPE-NA1 trial were categorized into predominantly deep grey matter infarcts vs. infarcts involving additional territories ("other infarcts"). Total infarct volume was manually segmented. Baseline characteristics and proportions of good outcome (primary outcome, defined as modified Rankin Score [mRS] 0-2 at 90 days), excellent outcome (mRS 0-1) and mortality were compared between patients with and without predominantly deep grey matter infarcts. Multivariable logistic regression with adjustment for baseline variables and total infarct volume was used to determine a possible association of predominantly deep grey matter infarcts and clinical outcome. RESULTS: Predominantly deep grey matter infarcts were seen in 316/1026 patients (30.8%). Compared to other patients, their ASPECTS was higher, collateral status and reperfusion quality were better and time to treatment was shorter. Good outcome was seen in 239/316 (75.6%) with vs. 374/704 (53.1%) without predominantly deep grey matter infarcts. After adjusting for baseline variables and total infarct volume, predominantly deep grey matter infarcts were independently associated with excellent outcome (adjOR: 1.45 [CI95: 1.04-2.02]), but not with good outcome (adjOR: 1.24 [CI95: 0.86-1.80]) or mortality (adjOR: 0.73 [CI95:0.39-1.35]) CONCLUSION: Predominantly deep grey matter infarct patterns were seen in 1/3rd of patients and were significantly associated with increased chances of excellent outcome, independent of patient baseline status and infarct size.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arteriopatías Oclusivas / Isquemia Encefálica / Accidente Cerebrovascular Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Neuroradiology Año: 2021 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arteriopatías Oclusivas / Isquemia Encefálica / Accidente Cerebrovascular Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Neuroradiology Año: 2021 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Alemania