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Effects of alpha lipoic acid on iron overload, lipid profile and oxidative stress indices in ß-thalassemia major patients: A cross-over randomised controlled clinical trial.
Sharifi-Zahabi, Elham; Abdollahzad, Hadi; Mostafa Nachvak, Seyed; Moloudi, Jalal; Golpayegani, Mohammad Reza; Asiaei, Sahar; Rezavand, Laya; Iraji, Zeynab; Jamshidi, Khadijeh.
Afiliación
  • Sharifi-Zahabi E; School of Nutrition Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • Abdollahzad H; School of Nutrition Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • Mostafa Nachvak S; Research Center for Environmental Determinants of Health, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • Moloudi J; School of Nutrition Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • Golpayegani MR; School of Nutrition Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • Asiaei S; Department of Pediatrics, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • Rezavand L; Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
  • Iraji Z; Imam Khomeini Comprehensive Health Services Center, Health Deputy, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • Jamshidi K; Department of Statistics and Epidemiology, Faculty of Health, Tabriz University of Medical Sciences, Tabriz, Iran.
Int J Clin Pract ; 75(6): e14062, 2021 Jun.
Article en En | MEDLINE | ID: mdl-33527721
AIMS: ß-Thalassemia major (ß-TM) is associated with iron overload, abnormal lipid levels and oxidative stress. Alpha lipoic acid (ALA) showed anti-oxidant and iron chelating properties, but its effect in ß-TM patients is unclear. We investigated the effects of ALA on iron levels, lipid profile and oxidative stress. METHODS: In this cross-over randomised clinical trial, 26 ß-TM patients were assigned to receive 600 mg/d ALA or placebo (corn starch), for 8 weeks with a 21-days washout period. Serum ferritin, total cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), LDL-C/HDL-C, total antioxidant capacity, malondialdehyde (MDA) and MDA/LDL-C were assessed at baseline and the end of each intervention phase. RESULTS: Twenty-two patients completed the study. Serum ferritin (P = .004), MDA (P = .025) and MDA/LDL-C ratio (P =.002) were decreased and HDL-C (P =.035) increased significantly during ALA consumption. In comparison with placebo, ALA decreased the serum ferritin significantly (P = .02). Also, the changes in serum ferritin between ALA and placebo (-123.1 ± 40.0 vs -34.3 ± 21.0, P =.03) was significant in women subgroup. ALA had no significant effects on the other biomarkers. CONCLUSION: The results of this study indicated that supplementation with 600 mg/d ALA may decrease serum ferritin in ß-TM. Further studies are needed to confirm the findings.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácido Tióctico / Talasemia beta / Sobrecarga de Hierro Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Female / Humans Idioma: En Revista: Int J Clin Pract Asunto de la revista: MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Irán Pais de publicación: India
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácido Tióctico / Talasemia beta / Sobrecarga de Hierro Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Female / Humans Idioma: En Revista: Int J Clin Pract Asunto de la revista: MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Irán Pais de publicación: India