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Herbicidal bio-assay of isocladosporin enantiomers and determination of its plausible absolute configuration.
Mankad, Yash; Das, Pronay; Pathan, Ejaj; Deshpande, M V; Reddy, D Srinivasa.
Afiliación
  • Mankad Y; Division of Organic Chemistry, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune, 411008, India.
  • Das P; Division of Organic Chemistry, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune, 411008, India.
  • Pathan E; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
  • Deshpande MV; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
  • Reddy DS; Biochemical Sciences Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune, 411008, India.
J Antibiot (Tokyo) ; 74(4): 280-284, 2021 04.
Article en En | MEDLINE | ID: mdl-33526864
A fungal metabolite, isocladosporin was isolated from natural fungus, Cladosporium cladosporioides in the mid of 90s. Due to the lack of optical rotation of isolated natural product sample, the absolute configuration of the natural product remained undetermined for more than two decades. Herein, we demonstrated an SAR study of enantiomers of isocladosporin in herbicidal bio-assay against wheat coleoptile. Using this study as a comparative tool we further proposed the plausible absolute configuration of natural isocladosporin for the first time. The assigned configuration was also supported through biogenetic precursors.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Isocumarinas / Herbicidas Límite: Animals Idioma: En Revista: J Antibiot (Tokyo) Año: 2021 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Isocumarinas / Herbicidas Límite: Animals Idioma: En Revista: J Antibiot (Tokyo) Año: 2021 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido