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Immune checkpoint inhibitor-induced takotsubo syndrome and diabetic ketoacidosis: rare reactions.
Oldfield, Kieran; Jayasinghe, Rohan; Niranjan, Selvanayagam; Chadha, Sameer.
Afiliación
  • Oldfield K; Department of Medicine, Gold Coast University Hospital, Southport, QLD, Australia kieran.oldfield@health.qld.gov.au.
  • Jayasinghe R; School of Medicine, Griffith University, Gold Coast, QLD, Australia.
  • Niranjan S; School of Medicine, Griffith University, Gold Coast, QLD, Australia.
  • Chadha S; Department of Cardiology, Gold Coast University Hospital, Southport, QLD, Australia.
BMJ Case Rep ; 14(2)2021 Feb 01.
Article en En | MEDLINE | ID: mdl-33526518
Immune checkpoint inhibitors (ICIs) are increasingly used to treat certain malignancies due to their higher efficacy compared with conventional chemotherapy. As familiarity with these agents increases, it is becoming apparent that a significant number of patients treated with ICIs experience adverse events. With time, more immune-related adverse events (IRAEs) are being recognised. It is important to be vigilant for IRAEs and recognise that a patient may have multiple IRAEs affecting multiple organ systems. Common cardiovascular adverse events associated with ICIs include myocarditis, arrhythmias and pericarditis. This case report identifies a patient presenting with takotsubo syndrome followed by ketoacidosis (associated with sodium-glucose transport protein 2 (SGLT2) inhibitor) in the setting of combination ipilimumab and nivolumab therapy for metastatic melanoma.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Cetoacidosis Diabética / Diabetes Mellitus Tipo 2 / Cardiomiopatía de Takotsubo / Inhibidores del Cotransportador de Sodio-Glucosa 2 / Inhibidores de Puntos de Control Inmunológico / Melanoma Tipo de estudio: Prognostic_studies Límite: Aged / Humans / Male Idioma: En Revista: BMJ Case Rep Año: 2021 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Cetoacidosis Diabética / Diabetes Mellitus Tipo 2 / Cardiomiopatía de Takotsubo / Inhibidores del Cotransportador de Sodio-Glucosa 2 / Inhibidores de Puntos de Control Inmunológico / Melanoma Tipo de estudio: Prognostic_studies Límite: Aged / Humans / Male Idioma: En Revista: BMJ Case Rep Año: 2021 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido