Your browser doesn't support javascript.
loading
The Value of Detecting Pathological Changes During Clot Formation in Early Disease Treatment-Naïve Breast Cancer Patients.
Goncalves, Julien Paul Nunes; de Waal, Greta Marie; Page, Martin Justin; Venter, Chantelle; Roberts, Timothy; Holst, Felix; Pretorius, Etheresia; Bester, Janette.
Afiliación
  • Goncalves JPN; Department of Physiology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
  • de Waal GM; Department of Physiological Sciences, Faculty of Science, Stellenbosch University, Stellenbosch, South Africa.
  • Page MJ; Department of Physiological Sciences, Faculty of Science, Stellenbosch University, Stellenbosch, South Africa.
  • Venter C; Department of Physiological Sciences, Faculty of Science, Stellenbosch University, Stellenbosch, South Africa.
  • Roberts T; Department of Physiological Sciences, Faculty of Science, Stellenbosch University, Stellenbosch, South Africa.
  • Holst F; Department of Biochemistry, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UK.
  • Pretorius E; University College London Hospital NHS Foundation Trust, 250 Euston Road, LondonNW1 2PB, UK.
  • Bester J; Department of Surgery, Steve Biko Academic Hospital, University of Pretoria, Pretoria, South Africa.
Microsc Microanal ; 27(2): 425-436, 2021 04.
Article en En | MEDLINE | ID: mdl-33526165
Breast cancer (BC) is one of the most prevalent forms of cancer in women worldwide. Clinical research indicates that BC patients are at an increased risk for thrombotic events, drastically decreasing their quality-of-life and treatment outcomes. There is ample evidence of this in the literature, but it is mainly focused on metastatic BC. Therefore, coagulopathies of nonmetastatic BC are understudied and require in-depth investigation. In this study, clot kinetics and ultrastructure were used to investigate treatment-naïve, nonmetastatic BC patients using scanning electron microscopy, Thromboelastography®, and confocal laser scanning microscopy. It was demonstrated that nonmetastatic BC patients exhibit minimal ultrastructural alterations of the clot components and no changes in the clot kinetics. However, BC patients presented changes to fibrinogen protein structure, compared to matched controls, using an amyloid-selective stain. Together, these findings suggest that coagulation dysfunction(s) in BC patients with early disease manifest at the microlevel, rather than the macrolevel. This study presents novel insights to a method that are more sensitive to coagulation changes in this specific patient group, emphasizing that the coagulation system may react in different forms to the disease, depending on the progression of the disease itself.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trombosis / Neoplasias de la Mama Aspecto: Patient_preference Límite: Female / Humans Idioma: En Revista: Microsc Microanal Año: 2021 Tipo del documento: Article País de afiliación: Sudáfrica Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trombosis / Neoplasias de la Mama Aspecto: Patient_preference Límite: Female / Humans Idioma: En Revista: Microsc Microanal Año: 2021 Tipo del documento: Article País de afiliación: Sudáfrica Pais de publicación: Reino Unido