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Synthesis of urea-modified magnetic nanocomposites iron oxide/carbon as a potential biomaterial produced by arc discharge in liquid medium and its in-vivo toxicity assessment.
Saraswati, Teguh Endah; Sari, Fitri Nela; Patimah, Patimah; Handayani, Nestri; Herbani, Yuliati; Nagatsu, Masaaki.
Afiliación
  • Saraswati TE; Department of Chemistry, Sebelas Maret University, Jl. Ir. Sutami 36 Surakarta 57126, Indonesia.
  • Sari FN; Department of Chemistry, Sebelas Maret University, Jl. Ir. Sutami 36 Surakarta 57126, Indonesia.
  • Patimah P; Department of Chemistry, Sebelas Maret University, Jl. Ir. Sutami 36 Surakarta 57126, Indonesia.
  • Handayani N; Department of Pharmacy, Sebelas Maret University, Jl. Ir. Sutami 36 A Surakarta, 57126, Indonesia.
  • Herbani Y; Research Center for Physics, Indonesian Institute of Sciences, Jl. Riset Gedung 442 Kawasan Puspitek, Tangerang Selatan, 15314, Indonesia.
  • Nagatsu M; Research Institute of Electronics, Shizuoka University, 3-5-1, Johoku, Naka-ku, Hamamatsu, 432-8561, Japan.
Biomed Phys Eng Express ; 7(2): 025006, 2021 01 30.
Article en En | MEDLINE | ID: mdl-33522495
Carbon-encapsulated magnetic nanoparticles are promising candidate materials for drug-delivery applications. However, due to their hydrophobic and aggregation properties, which indicate lower biocompatibility, proper surface modification of the carbon-based material is required. In the present study, we present the facile route to producing biocompatible magnetic nanocomposite iron oxide/carbon using the liquid medium arc-discharge method. The medium used was ethanol 50% with urea added in various concentrations. Using x-ray diffraction (XRD), the nanocomposite produced was confirmed to have a crystalline structure with distinctive peaks representing iron oxide, graphite, and urea. Fourier transform infrared spectroscopy (FTIR) analysis of the nanocomposite produced in ethanol/acetic acid or ethanol/urea medium shows several vibrations, including Fe-O, C-H, C-O, C=C, C-H, O-H, and C-N, which are intended to be the attached aromatic oxygen- and amine-containing functional groups. The nanocomposite particle was observed to have a core-shell structure that had an iron-compound core coated in a carbon shell possibly modified by polymeric urea groups. The presence of these groups suggested that the nanocomposite would be biocompatible with biological entities in the living body. Lastly, the prepared nanocomposite Fe3O4/C-urea underwent an in-vivo acute toxicity assay to confirm its toxicity. The highest dose of 2000 mg kg-1 BW in this study caused no deaths in the test animals even though cell damages were observed, especially in the liver. This highest dose is considered a maximum tolerable dose and is defined as practically non-toxic.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanocompuestos Límite: Animals / Humans Idioma: En Revista: Biomed Phys Eng Express Año: 2021 Tipo del documento: Article País de afiliación: Indonesia Pais de publicación: Reino Unido
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanocompuestos Límite: Animals / Humans Idioma: En Revista: Biomed Phys Eng Express Año: 2021 Tipo del documento: Article País de afiliación: Indonesia Pais de publicación: Reino Unido