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Relationship between guanosine triphosphate pathway and tetrahydrobiopterin in gestational diabetes mellitus.
Ünüvar, Songül; Melekoglu, Rauf; Salva, Emine; Acar, Ceren; Yasar, Seyma.
Afiliación
  • Ünüvar S; Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Inönü University, Malatya, Turkey.
  • Melekoglu R; Department of Obstetrics and Gynecology, Faculty of Medicine, Inönü University, Malatya, Turkey.
  • Salva E; Department of Pharmaceutical Biotechnolog, Faculty of Pharmacy, Inönü University, Malatya, Turkey.
  • Acar C; Department of Molecular Biology and Genetics, Faculty of Arts & Science, Inönü University, Malatya, Turkey.
  • Yasar S; Department of Biostatistics and Medical Informatics, Faculty of Medicine, Inönü University, Malatya, Turkey.
J Diabetes Metab Disord ; 19(2): 1391-1396, 2020 Dec.
Article en En | MEDLINE | ID: mdl-33520842
PURPOSE: The present study assesses the change in tetrahydrobiopterin (BH4), one of the most important products in the guanosine triphosphate (GTP) pathway and in other parameters that might affect nitric oxide (NO) production, in gestational diabetes mellitus (GDM). METHODS: The study included 100 healthy pregnant women and 100 women diagnosed with GDM. Serum levels of neopterin, BH4 and NO were measured. The levels of endothelial nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS) and guanosine triphosphate cyclohydrolase I (GCHI/GTPCH) gene expression were determined. RESULTS: It was found that diabetes led to an increase in neopterin and NO levels, and a decrease in BH4 levels. A stimulation was observed in eNOS gene expression in the GDM group when compared to the control group, while GCHI levels were found to decrease when compared to the control group. iNOS gene expression was detected in neither the healthy controls nor the patient group. CONCLUSIONS: Decreased NO bioavailability plays an important role in the progression of such macrovascular diseases as diabetes. BH4 levels decrease in diabetes patients, while the increased gene expression of GCHI reverses the diabetes-related BH4 deficiency and allows the endothelial cells to regain their ability to produce NO. Since GCHI is the rate-limiting enzyme in the biosynthesis of BH4, changes in GCHI levels directly affect the BH4 levels and the NO metabolism, leading to an increased risk of macrovascular complications. The significant increase in neopterin levels suggest that this is a potential biomarker for the early diagnosis of GDM.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Screening_studies Idioma: En Revista: J Diabetes Metab Disord Año: 2020 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Screening_studies Idioma: En Revista: J Diabetes Metab Disord Año: 2020 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Suiza