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Methotrexate-induced Transient Encephalopathy in an Adolescent and Young Adult Patient with Acute Lymphoblastic Leukemia.
Teshima, Kazuaki; Kume, Masaaki; Kondo, Rui; Shibata, Kenichi; Abe, Ko; Aono, Hiroaki; Fushimi, Susumu; Takahashi, Satoshi; Takahashi, Satsuki; Saito, Masahiro; Takahashi, Naoto.
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  • Teshima K; Department of Hematology, Hiraka General Hospital, Japan.
  • Kume M; Department of Hematology, Nephrology and Rheumatology, Akita University Graduate School of Medicine, Japan.
  • Kondo R; Department of Hematology, Hiraka General Hospital, Japan.
  • Shibata K; Department of Neurosurgery, Hiraka General Hospital, Japan.
  • Abe K; Department of Neurosurgery, Hiraka General Hospital, Japan.
  • Aono H; Department of Hematology, Hiraka General Hospital, Japan.
  • Fushimi S; Department of Hematology, Nephrology and Rheumatology, Akita University Graduate School of Medicine, Japan.
  • Takahashi S; Department of Neurosurgery, Hiraka General Hospital, Japan.
  • Takahashi S; Department of Neurosurgery, Hiraka General Hospital, Japan.
  • Saito M; Department of Radiology, Hiraka General Hospital, Japan.
  • Takahashi N; Department of Diagnostic Pathology, Hiraka General Hospital, Japan.
Intern Med ; 60(13): 2115-2118, 2021 Jul 01.
Article en En | MEDLINE | ID: mdl-33518561
A 17-year-old girl was diagnosed with acute lymphoblastic leukemia (ALL). After the administration of high-dose methotrexate (MTX) or intrathecal MTX, the patient experienced transient hemiparesis and motor aphasia. Diffusion-weighted magnetic resonance imaging showed a high-intensity lesion in the bilateral centrum semiovale, and a vasospasm was detected in the proximal segment of bilateral A1 on magnetic resonance angiography. Edaravone was administered, and leucovorin rescue treatment was continued; eventually, the patient's neurological symptoms completely resolved. This finding suggested that vasospasm might be a mechanism underlying MTX-induced transient encephalopathy in adolescent and young adult patients with ALL.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encefalopatías / Leucemia-Linfoma Linfoblástico de Células Precursoras Límite: Adolescent / Adult / Female / Humans Idioma: En Revista: Intern Med Asunto de la revista: MEDICINA INTERNA Año: 2021 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encefalopatías / Leucemia-Linfoma Linfoblástico de Células Precursoras Límite: Adolescent / Adult / Female / Humans Idioma: En Revista: Intern Med Asunto de la revista: MEDICINA INTERNA Año: 2021 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón