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Triterpenoid saponins and phenylpropanoid glycoside from the roots of Ardisia crenata and their cytotoxic activities.
Song, Ning-Ning; Yang, Lei-Min; Zhang, Min-Jie; An, Ren-Feng; Liu, Wei; Huang, Xue-Feng.
Afiliación
  • Song NN; School of Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
  • Yang LM; School of Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
  • Zhang MJ; School of Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
  • An RF; School of Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
  • Liu W; Department of Pharmacology, Nanjing Medical University, Nanjing 210029, China.
  • Huang XF; School of Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China. Electronic address: hxf@cpu.edu.cn.
Chin J Nat Med ; 19(1): 63-69, 2021 Jan.
Article en En | MEDLINE | ID: mdl-33516453
Two new triterpenoid saponins, ardisicrenoside R and S (1 and 2), and one new phenylpropanoid glycoside, ardicrephenin (3), along with five known compounds (4-8), were isolated from roots of Ardisia crenata. Their structures were elucidated on the basis of NMR spectroscopic data and chemical methods. Compounds 2-7 were evaluated for their cytotoxic activities against A549, MCF-7, HepG2 and MDA-MB-231 cell lines by MTT assay. Ardicrenin (6) showed significant cytotoxicity, with IC50 values of 1.17 ± 0.01, 1.19 ± 0.06, 3.52 ± 0.23, and 16.61 ± 1.02 µmol·L-1, respectively.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Saponinas / Triterpenos / Ardisia / Glicósidos / Antineoplásicos Fitogénicos Límite: Humans Idioma: En Revista: Chin J Nat Med Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Saponinas / Triterpenos / Ardisia / Glicósidos / Antineoplásicos Fitogénicos Límite: Humans Idioma: En Revista: Chin J Nat Med Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: China