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Evolutionary analysis of SARS-CoV-2 spike protein for its different clades.
Pereson, Matías J; Flichman, Diego M; Martínez, Alfredo P; Baré, Patricia; Garcia, Gabriel H; Di Lello, Federico A.
Afiliación
  • Pereson MJ; Facultad de Farmacia y Bioquímica, Instituto de Investigaciones en Bacteriología y Virología Molecular (IBaViM), Universidad de Buenos Aires, Buenos Aires, Argentina.
  • Flichman DM; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Ciudad Autónoma, de Buenos Aires, Argentina.
  • Martínez AP; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Ciudad Autónoma, de Buenos Aires, Argentina.
  • Baré P; Instituto de Investigaciones Biomédicas en Retrovirus y Síndrome de Inmunodeficiencia Adquirida (INBIRS) - Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad de Buenos Aires, Buenos Aires, Argentina.
  • Garcia GH; Virology Section, Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno "CEMIC", Buenos Aires, Argentina.
  • Di Lello FA; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Ciudad Autónoma, de Buenos Aires, Argentina.
J Med Virol ; 93(5): 3000-3006, 2021 05.
Article en En | MEDLINE | ID: mdl-33512021
The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become the main target for antiviral and vaccine development. Despite its relevance, e information is scarse about its evolutionary traces. The aim of this study was to investigate the diversification patterns of the spike for each clade of SARS-CoV-2 through different approaches. Two thousand and one hundred sequences representing the seven clades of the SARS-CoV-2 were included. Patterns of genetic diversifications and nucleotide evolutionary rate were estimated for the spike genomic region. The haplotype networks showed a star shape, where multiple haplotypes with few nucleotide differences diverge from a common ancestor. Four hundred seventy-nine different haplotypes were defined in the seven analyzed clades. The main haplotype, named Hap-1, was the most frequent for clades G (54%), GH (54%), and GR (56%) and a different haplotype (named Hap-252) was the most important for clades L (63.3%), O (39.7%), S (51.7%), and V (70%). The evolutionary rate for the spike protein was estimated as 1.08 × 10-3 nucleotide substitutions/site/year. Moreover, the nucleotide evolutionary rate after nine months of the pandemic was similar for each clade. In conclusion, the present evolutionary analysis is relevant as the spike protein of SARS-CoV-2 is the target for most therapeutic candidates; besides, changes in this protein could have consequences on viral transmission, response to antivirals and efficacy of vaccines. Moreover, the evolutionary characterization of clades improves knowledge of SARS-CoV-2 and deserves to be assessed in more detail as re-infection by different phylogenetic clades has been reported.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Evolución Molecular / Glicoproteína de la Espiga del Coronavirus / SARS-CoV-2 Límite: Humans Idioma: En Revista: J Med Virol Año: 2021 Tipo del documento: Article País de afiliación: Argentina Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Evolución Molecular / Glicoproteína de la Espiga del Coronavirus / SARS-CoV-2 Límite: Humans Idioma: En Revista: J Med Virol Año: 2021 Tipo del documento: Article País de afiliación: Argentina Pais de publicación: Estados Unidos