Your browser doesn't support javascript.
loading
Effects of aspirin on the long-term management of depression in older people: a double-blind randomised placebo-controlled trial.
Berk, Michael; Agustini, Bruno; Woods, Robyn L; Nelson, Mark R; Shah, Raj C; Reid, Christopher M; Storey, Elsdon; Fitzgerald, Sharyn M; Lockery, Jessica E; Wolfe, Rory; Mohebbi, Mohammadreza; Dodd, Seetal; Murray, Anne M; Stocks, Nigel; Fitzgerald, Paul B; Mazza, Catherine; McNeil, John J.
Afiliación
  • Berk M; Deakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, 75 Pigdon's Road, Waurn Ponds, Geelong, VIC, 3216, Australia. mikebe@barwonhealth.org.au.
  • Agustini B; School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, 3004, Australia. mikebe@barwonhealth.org.au.
  • Woods RL; Department of Psychiatry, University of Melbourne, Parkville, VIC, 3052, Australia. mikebe@barwonhealth.org.au.
  • Nelson MR; Orygen Youth Health, 35 Poplar Road, Parkville, VIC, 3052, Australia. mikebe@barwonhealth.org.au.
  • Shah RC; Deakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, 75 Pigdon's Road, Waurn Ponds, Geelong, VIC, 3216, Australia.
  • Reid CM; School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, 3004, Australia.
  • Storey E; Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, 7000, Australia.
  • Fitzgerald SM; Department of Family Medicine and the Rush Alzheimer's Disease Center, Rush University Medical Center, 600 South Paulina, Suite 1022, Chicago, IL, 60612, USA.
  • Lockery JE; School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, 3004, Australia.
  • Wolfe R; School of Public Health, Curtin University, Perth, WA, Australia.
  • Mohebbi M; School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, 3004, Australia.
  • Dodd S; School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, 3004, Australia.
  • Murray AM; School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, 3004, Australia.
  • Stocks N; School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, 3004, Australia.
  • Fitzgerald PB; Deakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, 75 Pigdon's Road, Waurn Ponds, Geelong, VIC, 3216, Australia.
  • Mazza C; Faculty of Health, Biostatistics Unit, Deakin University, Geelong, VIC, Australia.
  • McNeil JJ; Deakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, 75 Pigdon's Road, Waurn Ponds, Geelong, VIC, 3216, Australia.
Mol Psychiatry ; 26(9): 5161-5170, 2021 09.
Article en En | MEDLINE | ID: mdl-33504953
Late-life depression is common and often inadequately managed using existing therapies. Depression is also associated with increased markers of inflammation, suggesting a potential role for anti-inflammatory agents. ASPREE-D is a sub-study of ASPREE, a large multi-centre, population-based, double-blind, placebo-controlled trial of aspirin vs placebo in older Australian and American adults (median follow-up: 4.7 years) of whom 1879 were depressed at baseline. Participants were given 100 mg daily dose of aspirin or placebo. Depressive symptoms were assessed annually using the validated, self-rated short version of the Center for Epidemiological Studies Depression scale. There was a significant increase in depressive scores (0.6; 95% CI 0.2 to 0.9; χ2 (1) = 10.37; p = 0.001) and a decreased score in the mental health component of a quality of life scale (-0.7; 95% CI -1.4 to -0.1; χ2 (1) = 4.74; p = 0.029) in the aspirin group compared to the placebo group. These effects were greater in the first year of follow-up and persisted throughout the study, albeit with small to very small effect sizes. This study failed to demonstrate any benefit of aspirin in the long-term course of depression in this community-dwelling sample of older adults over a 5-year period, and identified an adverse effect of aspirin in the course of depression in those with pre-existing depressive symptoms.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aspirina / Depresión Tipo de estudio: Clinical_trials / Prognostic_studies Aspecto: Patient_preference Límite: Aged / Humans País/Región como asunto: Oceania Idioma: En Revista: Mol Psychiatry Asunto de la revista: BIOLOGIA MOLECULAR / PSIQUIATRIA Año: 2021 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aspirina / Depresión Tipo de estudio: Clinical_trials / Prognostic_studies Aspecto: Patient_preference Límite: Aged / Humans País/Región como asunto: Oceania Idioma: En Revista: Mol Psychiatry Asunto de la revista: BIOLOGIA MOLECULAR / PSIQUIATRIA Año: 2021 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido