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Effects of Chinese wolfberry and Astragalus extract on the antioxidant capacity of Tibetan pig liver.
Hao, Zhuang; Li, Zhen; Huo, Jinjin; Li, Jiandong; Liu, Fenghua; Yin, Peng.
Afiliación
  • Hao Z; College of Animal Science and Technology, Beijing University of Agriculture, Beijing, China.
  • Li Z; College of Animal Science and Technology, Beijing University of Agriculture, Beijing, China.
  • Huo J; College of Animal Science and Technology, Beijing University of Agriculture, Beijing, China.
  • Li J; College of Animal Science and Technology, Beijing University of Agriculture, Beijing, China.
  • Liu F; College of Animal Science and Technology, Beijing University of Agriculture, Beijing, China.
  • Yin P; Institute of Microbiology Chinese Academy of Sciences, Beijing, China.
PLoS One ; 16(1): e0245749, 2021.
Article en En | MEDLINE | ID: mdl-33503027
The objective of this study is to determine the effect of Chinese wolfberry (Lycium barbarum) and Astragalus (Astragalus membranaceus) extract (WAE) on the antioxidant capacity of Tibetan pig liver, and discussed the regulatory effect of WAE on the liver antioxidant mechanism. Twelve healthy 120-day-old Tibetan black pigs (35±2 kg) were divided randomly into two groups. The WAE group was fed a basal diet supplemented with 1% WAE for 90 days. The control group was fed the same diet, but without the WAE. We found that liver superoxide dismutase 1 (SOD1) activity (P<0.05), total antioxidative capacity (T-AOC) (P<0.05), and catalase (CAT) activity (P<0.01) significantly increased in the WAE group compared with the control group; malondialdehyde (MDA) content decreased, but this was not significant (P >0.05). Transcriptome sequencing analysis detected 106 differentially expressed genes (DEGs) related to oxidative stress. GO enrichment analysis showed these DEGs were involved in the positive regulation of reactive oxygen metabolism and biosynthesis, process regulation, and regulation of the oxidative stress response. KEGG Pathway enrichment analysis showed they were enriched in the PI3K-Akt, AMPK, Rap1, and peroxisome signaling pathways. The expression levels of key peroxisome biosynthesis genes (e.g., PEX3 and PEX11B) and key antioxidant genes (e.g., CAT and SOD1) were significantly higher in the WAE group than in the control group. The PRDX1 and PRDX5 content also was significantly higher in the WAE group. This study showed that the WAE regulated the antioxidant and anti-stress ability of Tibetan pig liver through a "peroxisome antioxidant-oxidant stress" signaling pathway.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Extractos Vegetales / Planta del Astrágalo / Lycium / Hígado / Antioxidantes Límite: Animals Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Extractos Vegetales / Planta del Astrágalo / Lycium / Hígado / Antioxidantes Límite: Animals Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos