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Cortical Mechanisms of Visual Hypersensitivity in Women at Risk for Chronic Pelvic Pain.
Kmiecik, Matthew J; Tu, Frank F; Silton, Rebecca L; Dillane, Katlyn E; Roth, Genevieve E; Harte, Steven E; Hellman, Kevin M.
Afiliación
  • Kmiecik MJ; Department of Ob/Gyn, NorthShore University HealthSystem, Evanston, IL, United States.
  • Tu FF; Department of Ob/Gyn, Pritzker School of Medicine, University of Chicago, Chicago, IL, United States.
  • Silton RL; Department of Ob/Gyn, NorthShore University HealthSystem, Evanston, IL, United States.
  • Dillane KE; Department of Ob/Gyn, Pritzker School of Medicine, University of Chicago, Chicago, IL, United States.
  • Roth GE; Department of Psychology, Loyola University Chicago, Chicago, IL, United States.
  • Harte SE; Department of Ob/Gyn, NorthShore University HealthSystem, Evanston, IL, United States.
  • Hellman KM; Department of Ob/Gyn, NorthShore University HealthSystem, Evanston, IL, United States.
medRxiv ; 2021 Jan 18.
Article en En | MEDLINE | ID: mdl-33501463
Multisensory hypersensitivity (MSH), which refers to persistent discomfort across sensory modalities, is a risk factor for chronic pain. Developing a better understanding of the neural contributions of disparate sensory systems to MSH may clarify its role in the development of chronic pain. We recruited a cohort of women ( n =147) enriched with participants with menstrual pain at risk for developing chronic pain. Visual sensitivity was measured using a periodic pattern-reversal stimulus during EEG. Self-reported visual unpleasantness ratings were also recorded. Bladder pain sensitivity was evaluated with an experimental bladder-filling task associated with early clinical symptoms of chronic pelvic pain. Visual stimulation induced unpleasantness was associated with bladder pain and evoked primary visual cortex excitation; however, the relationship between unpleasantness and cortical excitation was moderated by bladder pain. Thus, future studies aimed at reversing the progression of MSH into chronic pain should prioritize targeting of cortical mechanisms responsible for maladaptive sensory input integration.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Etiology_studies / Risk_factors_studies Idioma: En Revista: MedRxiv Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Etiology_studies / Risk_factors_studies Idioma: En Revista: MedRxiv Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos