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The Microfluidic Toolbox for Analyzing Exosome Biomarkers of Aging.
DeCastro, Jonalyn; Littig, Joshua; Chou, Peichi Peggy; Mack-Onyeike, Jada; Srinivasan, Amrita; Conboy, Michael J; Conboy, Irina M; Aran, Kiana.
Afiliación
  • DeCastro J; Keck Graduate Institute, The Claremont Colleges, Claremont, CA 91711, USA.
  • Littig J; Keck Graduate Institute, The Claremont Colleges, Claremont, CA 91711, USA.
  • Chou PP; Pitzer College, The Claremont Colleges, Claremont, CA 91711, USA.
  • Mack-Onyeike J; Keck Graduate Institute, The Claremont Colleges, Claremont, CA 91711, USA.
  • Srinivasan A; Claremont McKenna College, The Claremont Colleges, Claremont, CA 91711, USA.
  • Conboy MJ; Department of Bioengineering, University of California, Berkeley, CA 94720, USA.
  • Conboy IM; Department of Bioengineering, University of California, Berkeley, CA 94720, USA.
  • Aran K; Keck Graduate Institute, The Claremont Colleges, Claremont, CA 91711, USA.
Molecules ; 26(3)2021 Jan 20.
Article en En | MEDLINE | ID: mdl-33498573
As the fields of aging and neurological disease expand to liquid biopsies, there is a need to identify informative biomarkers for the diagnosis of neurodegeneration and other age-related disorders such as cancers. A means of high-throughput screening of biomolecules relevant to aging can facilitate this discovery in complex biofluids, such as blood. Exosomes, the smallest of extracellular vesicles, are found in many biofluids and, in recent years, have been found to be excellent candidates as liquid biopsy biomarkers due to their participation in intercellular communication and various pathologies such as cancer metastasis. Recently, exosomes have emerged as novel biomarkers for age-related diseases. Hence, the study of exosomes, their protein and genetic cargo can serve as early biomarkers for age-associated pathologies, especially neurodegenerative diseases. However, a disadvantage of exosome studies includes a lack in standardization of isolating, detecting, and profiling exosomes for downstream analysis. In this review, we will address current techniques for high-throughput isolation and detection of exosomes through various microfluidic and biosensing strategies and how they may be adapted for the detection of biomarkers of age-associated disorders.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento / Biomarcadores / Técnicas Analíticas Microfluídicas Límite: Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento / Biomarcadores / Técnicas Analíticas Microfluídicas Límite: Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza