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Efficacy evaluation of nilotinib treatment in different genomic subtypes of gastrointestinal stromal tumors: A meta-analysis and systematic review.
Zhao, Zekun; Zhang, Jie; Zhang, Wenbing; Tan, Siyuan; Wei, Hao-Tang; You, Jun; Guo, Shanshan; Wang, Jing; Chen, Ping; Xu, Yingying; Zong, Liang.
Afiliación
  • Zhao Z; Department of General Surgery, Tongji Hospital, Medical School of Tongji University, Shanghai, PR China.
  • Zhang J; Department of General Surgery, The Affiliated Hospital of Yangzhou University, Yangzhou, PR China.
  • Zhang W; Department of General Surgery, The First Affiliated Hospital of Xingjiang Medical University, Urumqi, Xinjiang Province, PR China.
  • Tan S; Department of General Surgery, The Affiliated Hospital of Yangzhou University, Yangzhou, PR China.
  • Wei HT; Department of Gastrointestinal Surgery, The Third Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, PR China.
  • You J; Department of Gastrointestinal Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, PR China.
  • Guo S; Department of General Surgery, The Affiliated Hospital of Yangzhou University, Yangzhou, PR China.
  • Wang J; School of Clinical Medicine, Dali University, Dali, Yunnan 671000, PR China.
  • Chen P; Department of General Surgery, The Affiliated Hospital of Yangzhou University, Yangzhou, PR China.
  • Xu Y; Yizheng People's Hospital, Clinical Medical College, Yangzhou University, Yangzhou 211400, Jiangsu Province, China. Electronic address: 237721898@qq.com.
  • Zong L; Changzhi People's Hospital, The Affiliated Hospital of Changzhi Medical College, Changzhi 046000, Shanxi Province, China. Electronic address: 250537471@qq.com.
Curr Probl Cancer ; 45(3): 100705, 2021 06.
Article en En | MEDLINE | ID: mdl-33495025
Nilotinib has been used as a third-line drug for gastrointestinal stromal tumors (GISTs) after a failure of sunitinib. In this study, we aimed to evaluate the efficacy of nilotinib in different genomic subtypes of GISTs. We searched the English articles through EMBASE, Cochrane Library and PubMed Database regarding to the use of nilotinib on GISTs, which published up to February 15, 2019. Inclusion criteria were: GISTs patients received nilotinib in a clinical trial and had detailed genetic subtype records (such as KIT exon 9, KIT exon 11, or PDGFRA mutations, or wild-type). The clinical benefit rate was used to assess the efficacy of nilotinib. A total of 3 studies involving 218 GISTs were included in this meta-analysis. The overall OR (KIT group vs WT group) was 3.26 (95% CI: 1.14-9.28; P = 0.027, Pheterogeneity = 0.613). The overall OR in KIT exon 11 group vs WT group was 5.30 (95% CI: 1.79-15.68; P = 0.003, Pheterogeneity = 0.409). The overall OR in KIT exon 9 group vs WT group was 0.13 (95% CI: 0.02-0.86; P = 0.035, Pheterogeneity = 0.229). The overall OR in KIT exon 11 group vs exon 9 group was 9.96 (95% CI: 0.39-254.66; P < 0.0001, Pheterogeneity = 0.024). Different genotypes of GISTs showed different responses to nilotinib, and KIT exon 11-mutant GISTs mostly benefited from nilotinib, followed by KIT exon 9-mutant or WT one.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirimidinas / Tumores del Estroma Gastrointestinal / Neoplasias Gastrointestinales Tipo de estudio: Systematic_reviews Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Curr Probl Cancer Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirimidinas / Tumores del Estroma Gastrointestinal / Neoplasias Gastrointestinales Tipo de estudio: Systematic_reviews Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Curr Probl Cancer Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos