INTRODUCTION: Quality work environment has been established as a marker of employee value creation. A plethora of qualitative evidence suggested that sustained focus on employee satisfaction through changes in the work environment, communication of patient-centered care strategic vision, management of staff workload, and workplace social support are factors that stimulate Patient-centered care. Yet, it seems that the effect of work environment on the patient-centered behavior of hospital employees has not been statistically estimated, and it is unclear which of the elements of the work environment best predict patient-centered behavior. METHODS: Using a survey design and quantitative methods to gather and analyze data, a sample of 179 respondents from three district hospitals were included in the study using a multi-stage proportional sampling technique. Data were collected using self-administered Likert item questionnaires. Simple linear regression was used to estimate the influence of work environment elements on patient-centered behavior. Stepwise multiple regression was used to determine the best predictors of patient-centered behavior of hospital employees. RESULTS: Perceived internal communication of patient-centered care strategies (ß = 0.23; P<0.001), supervisor support (ß = 0.31; P<0.001), coworker support (ß = 0.50; P<0.001), and working conditions (ß = 0.18; P<0.013) had a positive significant effect on patient-centered behavior of employees. Good predictors of employees' patient-centered behavior were perceived coworker support (ß = 0.51; P<0.001) and job characteristics (ß = 0.16; P<0.01). CONCLUSION: The work environment of hospital employees significantly affects their patient-centered behavior. Co-worker support and job characteristics were the best predictors of the patient-centered behavior of hospital employees. Hospitals Managers seeking to improve patient-centered behavior through employee value creation may consider improved job characteristics in combination with workplace social support and or communication of PCC strategies and goals.