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The effect of paleolithic diet on glucose metabolism and lipid profile among patients with metabolic disorders: a systematic review and meta-analysis of randomized controlled trials.
Sohouli, Mohammad Hassan; Fatahi, Somaye; Lari, Abolfazl; Lotfi, Mojtaba; Seifishahpar, Maryam; Gaman, Mihnea-Alexandru; Rahideh, Seyedeh Tayebeh; AlBatati, Saud K; AlHossan, Abdullah M; Alkhalifa, Sara A; Alomar, Sara A; Abu-Zaid, Ahmed.
Afiliación
  • Sohouli MH; Faculty of Public Health Branch, Student Research Committee, Iran University of Medical Sciences, Tehran, Iran.
  • Fatahi S; Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
  • Lari A; Faculty of Public Health Branch, Student Research Committee, Iran University of Medical Sciences, Tehran, Iran.
  • Lotfi M; Pediatric Gastroenterology, Hepatology and Nutrition Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Seifishahpar M; Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
  • Gaman MA; Department of Pediatric Endocrinology and Metabolism, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Rahideh ST; Faculty of Nutrition and Food Technology, Department of Clinical Nutrition and Dietetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • AlBatati SK; "Carol Davila" University of Medicine and Pharmacy, 8 Eroii Sanitari Boulevard, Bucharest, Romania & Center of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, Romania.
  • AlHossan AM; Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
  • Alkhalifa SA; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
  • Alomar SA; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
  • Abu-Zaid A; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
Crit Rev Food Sci Nutr ; 62(17): 4551-4562, 2022.
Article en En | MEDLINE | ID: mdl-33492173
OBJECTIVE: Several randomized clinical trials (RCTs) have investigated the effects of the Paleolithic diet (PD) in adult patients suffering from metabolic disorders. However, the results of these RCTs are conflicting. Therefore, we conducted a systematic review and meta-analysis to assess the effects of the PD in patients with metabolic disorders. METHODS: We searched the PubMed/Medline, Scopus, Cochrane Databases, Google Scholar, Web of Science, and Embase databases up to June, 2020. The data were pooled using a random-effects model. From the eligible publications, 10 articles were selected for inclusion in this systematic review and meta-analysis. The meta-analysis was performed using a random-effects model. The heterogeneity was determined using the I2 statistics and the Cochrane Q test. RESULTS: The pooled results from the random-effects model showed a significant reduction of the homeostatic model assessment of insulin resistance (HOMA-IR) (weighted mean difference, WMD: -0.39, 95% CI: -0.70, -0.08), fasting insulin (WMD: -12.17 µU/mL, 95% CI: -24.26, -0.08), total cholesterol (WMD: -0.32 mmol/l, 95% CI: -0.49, -0.15), triglycerides (WMD: -0.29 mmol/L, 95% CI: -0.42, -0.16), low-density lipoprotein cholesterol (WMD: -0.35 mmol/L, 95% CI: -0.67, -0.03), blood pressure (BP)(WMD - 5.89 mmHg; 95% CI - 9.973 to - 1.86 for the systolic BP and WMD - 4.01 mmHg; 95% CI - 6.21 to - 1.80 for the diastolic BP values) and C-reactive protein (CRP) levels (WMD: -0.84, mg/L, 95% CI: -1.62, -0.06) in the PD group versus control group. CONCLUSIONS: Our findings provide better insights into the effect of the PD on the modulation of the glucose and lipid metabolism factors in patients with metabolic disorders, providing comprehensive information for the development of future RCTs with a high quality design.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resistencia a la Insulina / Dieta Paleolítica Tipo de estudio: Clinical_trials / Prognostic_studies / Systematic_reviews Límite: Adult / Humans Idioma: En Revista: Crit Rev Food Sci Nutr Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2022 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resistencia a la Insulina / Dieta Paleolítica Tipo de estudio: Clinical_trials / Prognostic_studies / Systematic_reviews Límite: Adult / Humans Idioma: En Revista: Crit Rev Food Sci Nutr Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2022 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Estados Unidos