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Natural Cycle Results in Lower Implantation Failure than Ovarian Stimulation in Advanced-Age Poor Responders Undergoing IVF: Fertility Outcomes from 585 Patients.
De Marco, Maria Paola; Montanari, Giulia; Ruscito, Ilary; Giallonardo, Annalise; Ubaldi, Filippo Maria; Rienzi, Laura; Costanzi, Flavia; Caserta, Donatella; Schimberni, Mauro; Schimberni, Matteo.
Afiliación
  • De Marco MP; Gynecology Unit, Sant'Andrea University Hospital, Department of Medical and Surgical Sciences and Translational Medicine, Medicine and Psychology Faculty, Sapienza University of Rome, Rome, Italy. demarco.mariapaola@gmail.com.
  • Montanari G; Gynecology Unit, Sant'Andrea University Hospital, Department of Medical and Surgical Sciences and Translational Medicine, Medicine and Psychology Faculty, Sapienza University of Rome, Rome, Italy.
  • Ruscito I; Gynecology Unit, Sant'Andrea University Hospital, Department of Medical and Surgical Sciences and Translational Medicine, Medicine and Psychology Faculty, Sapienza University of Rome, Rome, Italy.
  • Giallonardo A; Clinica Valle Giulia, G.E.N.E.R.A. Centers for Reproductive Medicine, Rome, Italy.
  • Ubaldi FM; Clinica Valle Giulia, G.E.N.E.R.A. Centers for Reproductive Medicine, Rome, Italy.
  • Rienzi L; Clinica Valle Giulia, G.E.N.E.R.A. Centers for Reproductive Medicine, Rome, Italy.
  • Costanzi F; Gynecology Unit, Sant'Andrea University Hospital, Department of Medical and Surgical Sciences and Translational Medicine, Medicine and Psychology Faculty, Sapienza University of Rome, Rome, Italy.
  • Caserta D; Gynecology Unit, Sant'Andrea University Hospital, Department of Medical and Surgical Sciences and Translational Medicine, Medicine and Psychology Faculty, Sapienza University of Rome, Rome, Italy.
  • Schimberni M; Gynecology Unit, Sant'Andrea University Hospital, Department of Medical and Surgical Sciences and Translational Medicine, Medicine and Psychology Faculty, Sapienza University of Rome, Rome, Italy.
  • Schimberni M; Clinica Valle Giulia, G.E.N.E.R.A. Centers for Reproductive Medicine, Rome, Italy.
Reprod Sci ; 28(7): 1967-1973, 2021 07.
Article en En | MEDLINE | ID: mdl-33483890
To compare pregnancy rate and implantation rate in poor responder women, aged over 40 years, who underwent natural cycle versus conventional ovarian stimulation. This is a retrospective single-center cohort study conducted at the GENERA IVF program, Rome, Italy, between September 2012 and December 2018, including only poor responder patients, according to Bologna criteria, of advanced age, who underwent IVF treatment through Natural Cycle or conventional ovarian stimulation. Between September 2012 and December 2018, 585 patients were included within the study. Two hundred thirty patients underwent natural cycle and 355 underwent conventional ovarian stimulation. In natural cycle group, both pregnancy rate per cycle (6.25 vs 12.89%, respectively, p = 0.0001) and pregnancy rate per patient101 with at least one embryo-transfer (18.85 vs 28.11% respectively, p = 0.025) resulted significant reduced. Pregnancy rate per patient managed with conventional ovarian stimulation resulted not significantly different compared with natural cycle (19.72 vs 15.65% respectively, p = 0.228), but embryo implantation rate was significantly higher in patients who underwent natural cycle rather than patient subjected to conventional ovarian stimulation (13 vs 8.28% respectively, p = 0.0468). No significant difference could be detected among the two groups in terms of abortion rate (p = 0.2915) or live birth pregnancy (p = 0.2281). Natural cycle seems to be a valid treatment in patients over 40 years and with a low ovarian reserve, as an alternative to conventional ovarian stimulation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inducción de la Ovulación / Implantación del Embrión / Fertilización In Vitro / Índice de Embarazo / Infertilidad Femenina Tipo de estudio: Observational_studies Límite: Female / Humans / Pregnancy Idioma: En Revista: Reprod Sci Asunto de la revista: MEDICINA REPRODUTIVA Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inducción de la Ovulación / Implantación del Embrión / Fertilización In Vitro / Índice de Embarazo / Infertilidad Femenina Tipo de estudio: Observational_studies Límite: Female / Humans / Pregnancy Idioma: En Revista: Reprod Sci Asunto de la revista: MEDICINA REPRODUTIVA Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos