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Therapygenetic effects of 5-HTTLPR on cognitive-behavioral therapy in anxiety disorders: A meta-analysis.
Schiele, Miriam A; Reif, Andreas; Lin, Jiaxi; Alpers, Georg W; Andersson, Evelyn; Andersson, Gerhard; Arolt, Volker; Bergström, Jan; Carlbring, Per; Eley, Thalia C; Esquivel, Gabriel; Furmark, Tomas; Gerlach, Alexander L; Hamm, Alfons; Helbig-Lang, Sylvia; Hudson, Jennifer L; Lang, Thomas; Lester, Kathryn J; Lindefors, Nils; Lonsdorf, Tina B; Pauli, Paul; Richter, Jan; Rief, Winfried; Roberts, Susanna; Rück, Christian; Schruers, Koen R J; Thiel, Christiane; Wittchen, Hans-Ulrich; Domschke, Katharina; Weber, Heike; Lueken, Ulrike.
Afiliación
  • Schiele MA; Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address: miriam.schiele@uniklinik-freiburg.de.
  • Reif A; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany.
  • Lin J; Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Alpers GW; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany.
  • Andersson E; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
  • Andersson G; Department of Behavioural Sciences and Learning, Division of Psychology, Linköping University, Linköping, Sweden.
  • Arolt V; Institute of Translational Psychiatry, Department of Psychiatry and Psychotherapy, University of Muenster, Muenster, Germany.
  • Bergström J; Department of Psychology, Stockholm University, Stockholm, Sweden.
  • Carlbring P; Department of Psychology, Stockholm University, Stockholm, Sweden.
  • Eley TC; King's College London, Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, London, United Kingdom.
  • Esquivel G; School for Mental Health and Neuroscience, Maastricht University, The Netherlands and Mondriaan Mental Health Center, Maastricht, The Netherlands.
  • Furmark T; Department of Psychology, Uppsala University, Uppsala, Sweden.
  • Gerlach AL; Department of Clinical Psychology and Psychotherapy, University of Cologne, Cologne, Germany.
  • Hamm A; Department of Psychology, University of Greifswald, Greifswald, Germany.
  • Helbig-Lang S; Department of Clinical Psychology and Psychotherapy, University of Hamburg, Hamburg, Germany.
  • Hudson JL; Department of Psychology, Centre for Emotional Health, Macquarie University, Sydney, NSW, Australia.
  • Lang T; Christoph-Dornier-Foundation for Clinical Psychology, Bremen, Germany; Department of Psychology and Methods, Jacobs University Bremen, Germany.
  • Lester KJ; School of Psychology, University of Sussex, Brighton, United Kingdom.
  • Lindefors N; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Stockholm Health Care Services, Region Stockholm, Sweden.
  • Lonsdorf TB; Institute for Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Pauli P; Department of Psychology (Biological Psychology, Clinical Psychology, and Psychotherapy), and Center of Mental Health, Julius-Maximilians-Universität Würzburg, Würzburg, Germany.
  • Richter J; Department of Psychology, University of Greifswald, Greifswald, Germany.
  • Rief W; Division of Clinical Psychology and Psychotherapy, Department of Psychology, Philipps University Marburg, Marburg, Germany.
  • Roberts S; King's College London, Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, London, United Kingdom.
  • Rück C; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Stockholm Health Care Services, Region Stockholm, Sweden.
  • Schruers KRJ; School for Mental Health and Neuroscience, Maastricht University, The Netherlands and Mondriaan Mental Health Center, Maastricht, The Netherlands.
  • Thiel C; Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Wittchen HU; Institute of Clinical Psychology and Psychotherapy, Technische Universität Dresden, Dresden, Germany.
  • Domschke K; Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Center for Basics in NeuroModulation, Faculty of Medicine, University of Freiburg, Germany.
  • Weber H; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany; Center of Mental Health, Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Würzburg, Germany.
  • Lueken U; Center of Mental Health, Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Würzburg, Germany; Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.
Eur Neuropsychopharmacol ; 44: 105-120, 2021 03.
Article en En | MEDLINE | ID: mdl-33483252
There is a recurring debate on the role of the serotonin transporter gene linked polymorphic region (5-HTTLPR) in the moderation of response to cognitive behavioral therapy (CBT) in anxiety disorders. Results, however, are still inconclusive. We here aim to perform a meta-analysis on the role of 5-HTTLPR in the moderation of CBT outcome in anxiety disorders. We investigated both categorical (symptom reduction of at least 50%) and dimensional outcomes from baseline to post-treatment and follow-up. Original data were obtained from ten independent samples (including three unpublished samples) with a total of 2,195 patients with primary anxiety disorder. No significant effects of 5-HTTLPR genotype on categorical or dimensional outcomes at post and follow-up were detected. We conclude that current evidence does not support the hypothesis of 5-HTTLPR as a moderator of treatment outcome for CBT in anxiety disorders. Future research should address whether other factors such as long-term changes or epigenetic processes may explain further variance in these complex gene-environment interactions and molecular-genetic pathways that may confer behavioral change following psychotherapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Terapia Cognitivo-Conductual / Proteínas de Transporte de Serotonina en la Membrana Plasmática Tipo de estudio: Systematic_reviews Límite: Humans Idioma: En Revista: Eur Neuropsychopharmacol Asunto de la revista: PSICOFARMACOLOGIA Año: 2021 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Terapia Cognitivo-Conductual / Proteínas de Transporte de Serotonina en la Membrana Plasmática Tipo de estudio: Systematic_reviews Límite: Humans Idioma: En Revista: Eur Neuropsychopharmacol Asunto de la revista: PSICOFARMACOLOGIA Año: 2021 Tipo del documento: Article Pais de publicación: Países Bajos