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Development of aortic valve stenosis in myeloperoxidase antineutrophil cytoplasmic antibody-associated vasculitis with renal involvement.
Hasegawa, Midori; Iwasaki, Jin; Sugiyama, Satoshi; Ishihara, Takuma; Yamamoto, Yoshihiro; Asada, Hiroaki; Koide, Shigehisa; Hayashi, Hiroki; Takahashi, Kazuo; Inaguma, Daijo; Yuzawa, Yukio; Tsuboi, Naotake.
Afiliación
  • Hasegawa M; Department of Nephrology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
  • Iwasaki J; Tokoname City Hospital, Tokoname, Aichi, Japan.
  • Sugiyama S; Kanayama Clinic, Nagoya, Aichi, Japan.
  • Ishihara T; Gifu University Hospital Innovative and Clinical Research Promotion Center, Gifu City, Gifu, Japan.
  • Yamamoto Y; Toyota Memorial Hospital, Toyota, Aichi, Japan.
  • Asada H; Okazaki City Hospital, Okazaki, Aichi, Japan.
  • Koide S; Department of Nephrology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
  • Hayashi H; Department of Nephrology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
  • Takahashi K; Department of Nephrology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
  • Inaguma D; Department of Biomedical Molecular Sciences, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
  • Yuzawa Y; Department of Internal Medicine, Fujita Health University Bantane Hospital, Nagoya, Japan.
  • Tsuboi N; Department of Nephrology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
PLoS One ; 16(1): e0245869, 2021.
Article en En | MEDLINE | ID: mdl-33481903
INTRODUCTION: Degenerative aortic valve stenosis (AS) is a chronic progressive disease that resembles atherosclerosis development. Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is reportedly associated with accelerated atherosclerosis. This study aimed to examine the development of AS in patients with myeloperoxidase-AAV (MPO-AAV) with renal involvement at more than 1 year after the onset of vasculitis. METHODS: We performed a retrospective review of clinical records of MPO-AAV patients with renal involvement without AS at the onset of vasculitis who were treated in three hospitals and three dialysis clinics. RESULTS: The study included 97 MPO-AAV patients with renal involvement and 230 control patients with chronic kidney disease (CKD). Among them, 64 patients had AS. The prevalence rates of AS were 28.9% and 15.7% in MPO-AAV and control patients, respectively (p = 0.006). The multivariable logistic regression analysis showed that MPO-AAV, dialysis dependence, and hypertension were independently associated factors for AS. In MPO-AAV patients, systolic blood pressure was positively significantly associated with AS, whereas glucocorticoid dose of induction therapy was negatively significantly associated. The use of cyclophosphamide tended to be negatively associated with AS. The survival rate was significantly lower for patients with AS than for those without AS. CONCLUSIONS: The AS prevalence rate was significantly higher in MPO-AAV patients at more than 1 year after the onset of vasculitis than in control CKD patients. Therefore, regular monitoring of echocardiography during MPO-AAV treatment is suggested.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estenosis de la Válvula Aórtica / Peroxidasa / Vasculitis Asociada a Anticuerpos Citoplasmáticos Antineutrófilos / Riñón Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estenosis de la Válvula Aórtica / Peroxidasa / Vasculitis Asociada a Anticuerpos Citoplasmáticos Antineutrófilos / Riñón Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos