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Fatty Acid Derivatives Isolated from the Oil of Persea americana (Avocado) Protects against Neomycin-Induced Hair Cell Damage.
Park, SeonJu; Jeong, Seo Yule; Nam, Youn Hee; Park, Jun Hyung; Rodriguez, Isabel; Shim, Ji Heon; Yasmin, Tamanna; Kwak, Hee Jae; Oh, Youngse; Oh, Mira; Lee, Kye Wan; Lee, Jung Suk; Kim, Do Hoon; Park, Yu Hwa; Moon, In Seok; Choung, Se-Young; Jeong, Kwang Won; Hong, Bin Na; Kim, Seung Hyun; Kang, Tong Ho.
Afiliación
  • Park S; Chuncheon Center, Korea Basic Science Institute (KBSI), Chuncheon 24341, Korea.
  • Jeong SY; Department of Oriental Medicine Biotechnology, College of Life Sciences and Graduate School of Biotechnology, Kyung Hee University, Gyeonggi 17104, Korea.
  • Nam YH; Department of Oriental Medicine Biotechnology, College of Life Sciences and Graduate School of Biotechnology, Kyung Hee University, Gyeonggi 17104, Korea.
  • Park JH; Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon 21983, Korea.
  • Rodriguez I; Department of Oriental Medicine Biotechnology, College of Life Sciences and Graduate School of Biotechnology, Kyung Hee University, Gyeonggi 17104, Korea.
  • Shim JH; Department of Oriental Medicine Biotechnology, College of Life Sciences and Graduate School of Biotechnology, Kyung Hee University, Gyeonggi 17104, Korea.
  • Yasmin T; Department of Oriental Medicine Biotechnology, College of Life Sciences and Graduate School of Biotechnology, Kyung Hee University, Gyeonggi 17104, Korea.
  • Kwak HJ; Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon 21983, Korea.
  • Oh Y; Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon 21983, Korea.
  • Oh M; Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon 21983, Korea.
  • Lee KW; R&D Center, Dongkook Pharm. Co. Ltd., Gyeonggi 16229, Korea.
  • Lee JS; R&D Center, Dongkook Pharm. Co. Ltd., Gyeonggi 16229, Korea.
  • Kim DH; R&D Center, Dongkook Pharm. Co. Ltd., Gyeonggi 16229, Korea.
  • Park YH; R&D Center, Dongkook Pharm. Co. Ltd., Gyeonggi 16229, Korea.
  • Moon IS; Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul 03722, Korea.
  • Choung SY; Department of Preventive Pharmacy and Toxicology, College of Pharmacy, Kyung Hee University, Seoul 02453, Korea.
  • Jeong KW; Gachon Institute of Pharmaceutical Sciences, College of Pharmacy, Gachon University, Incheon 21936, Korea.
  • Hong BN; Department of Oriental Medicine Biotechnology, College of Life Sciences and Graduate School of Biotechnology, Kyung Hee University, Gyeonggi 17104, Korea.
  • Kim SH; Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon 21983, Korea.
  • Kang TH; Department of Oriental Medicine Biotechnology, College of Life Sciences and Graduate School of Biotechnology, Kyung Hee University, Gyeonggi 17104, Korea.
Plants (Basel) ; 10(1)2021 Jan 18.
Article en En | MEDLINE | ID: mdl-33477487
Avocado oil is beneficial to human health and has been reported to have beneficial effects on sensorineural hearing loss (SNHL). However, the compounds in avocado oil that affect SNHL have not been identified. In this study, we identified 20 compounds from avocado oil, including two new and 18 known fatty acid derivatives, using extensive spectroscopic analysis. The efficacy of the isolated compounds for improving SNHL was investigated in an ototoxic zebrafish model. The two new compounds, namely (2R,4R,6Z)-1,2,4-trihydroxynonadec-6-ene and (2R,4R)-1,2,4-trihydroxyheptadecadi-14,16-ene (compounds 1 and 2), as well as compounds 7, 9, 14, 17 and 19 showed significant improvement in damaged hair cells in toxic zebrafish. These results led to the conclusion that compounds from avocado oil as well as oil itself have a regenerative effect on damaged otic hair cells in ototoxic zebrafish.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Plants (Basel) Año: 2021 Tipo del documento: Article Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Plants (Basel) Año: 2021 Tipo del documento: Article Pais de publicación: Suiza