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A covalent p97/VCP ATPase inhibitor can overcome resistance to CB-5083 and NMS-873 in colorectal cancer cells.
Zhang, Gang; Li, Shan; Wang, Feng; Jones, Amanda C; Goldberg, Alexander F G; Lin, Benjamin; Virgil, Scott; Stoltz, Brian M; Deshaies, Raymond J; Chou, Tsui-Fen.
Afiliación
  • Zhang G; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, United States.
  • Li S; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, United States.
  • Wang F; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, United States.
  • Jones AC; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, 91125, United States.
  • Goldberg AFG; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, 91125, United States.
  • Lin B; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, 91125, United States.
  • Virgil S; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, 91125, United States.
  • Stoltz BM; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, 91125, United States. Electronic address: stoltz@caltech.edu.
  • Deshaies RJ; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, United States; Howard Hughes Medical Institute, Chevy Chase, MD, 20815, United States. Electronic address: rdii2003@gmail.com.
  • Chou TF; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, United States; Proteome Exploration Laboratory, Beckman Institute, California Institute of Technology, Pasadena, CA, 91125, United States. Electronic address: tfchou@caltech.edu.
Eur J Med Chem ; 213: 113148, 2021 Mar 05.
Article en En | MEDLINE | ID: mdl-33476933
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Nucleares / Neoplasias Colorrectales / Adenosina Trifosfatasas / Resistencia a Antineoplásicos / Inhibidores Enzimáticos / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Francia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Nucleares / Neoplasias Colorrectales / Adenosina Trifosfatasas / Resistencia a Antineoplásicos / Inhibidores Enzimáticos / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Francia