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The Relationship Between Matrix Metalloproteinase-8 in After Birth Oral Fluid and Acute Histologic Chorioamnionitis in Preterm Delivery.
Choi, Soo Ran; Kim, Taehee; Kim, Yejeong; Jung, Sugyung; Choi, Suk Jin.
Afiliación
  • Choi SR; Department of Obstetrics and Gynecology, Inha University College of Medicine, Inha University Hospital, 27, Inhang-Ro, Jung-Gu, Incheon, 22332, South Korea. csran@inha.ac.kr.
  • Kim T; Department of Obstetrics and Gynecology, Inha University College of Medicine, Inha University Hospital, 27, Inhang-Ro, Jung-Gu, Incheon, 22332, South Korea.
  • Kim Y; Department of Obstetrics and Gynecology, Inha University College of Medicine, Inha University Hospital, 27, Inhang-Ro, Jung-Gu, Incheon, 22332, South Korea.
  • Jung S; Department of Obstetrics and Gynecology, Inha University College of Medicine, Inha University Hospital, 27, Inhang-Ro, Jung-Gu, Incheon, 22332, South Korea.
  • Choi SJ; Department of Pathology, Inha University College of Medicine, Inha University Hospital, Incheon, South Korea.
Reprod Sci ; 28(7): 2023-2028, 2021 07.
Article en En | MEDLINE | ID: mdl-33475979
Elevated concentration of matrix metalloproteinase-8 (MMP-8) in amniotic fluid is a known predictor of intra-amniotic inflammation and infection. The aim of this study was to determine the nature of the association between MMP-8 levels in oral fluid obtained immediately after birth and acute histologic chorioamnionitis (HCA) in preterm delivery. Oral fluid was collected from 93 consecutive preterm birth newborns between gestational weeks of 24 + 0 and 36 + 6. Concentrations of MMP-8 and interleukin-8 (IL-8) in after birth oral fluid were measured by ELISA. Acute HCA was defined as the presence of neutrophils infiltration into chorioamnionic membranes. Logistic regression analysis was used for the statistical analysis. MMP-8 concentrations in after birth oral fluid were significantly higher for women with acute HCA than for those without (median [range]; 68.3 ng/mL [0.06-12,479.6] vs. 10.2 ng/mL [0.06-1808.2], p = 0.002). A strong association was observed between MMP-8 and IL-8 levels (γ2 = 0.87, p < 0.01). The cutoff level of MMP-8 in after birth oral fluid for acute HCA was 39.7 ng/mL (sensitivity of 63.2%, specificity of 81.1%). Multivariable logistic regression analysis showed MMP-8 in after birth oral fluid had an odds ratio of 4.17 for acute HCA (95% confidence interval [CI] = 1.08-16.17, p = 0.03). An elevated MMP-8 level in after birth oral fluid is associated with acute HCA in preterm birth. Newborn oral fluid immediately after birth might provide another source for information of intra-amniotic condition just before birth.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Corioamnionitis / Metaloproteinasa 8 de la Matriz / Nacimiento Prematuro / Líquido Amniótico / Trabajo de Parto Prematuro Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Reprod Sci Asunto de la revista: MEDICINA REPRODUTIVA Año: 2021 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Corioamnionitis / Metaloproteinasa 8 de la Matriz / Nacimiento Prematuro / Líquido Amniótico / Trabajo de Parto Prematuro Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Reprod Sci Asunto de la revista: MEDICINA REPRODUTIVA Año: 2021 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Estados Unidos