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Impaired host resistance to Salmonella during helminth co-infection is restored by anthelmintic treatment prior to bacterial challenge.
Brosschot, Tara P; Lawrence, Katherine M; Moeller, Brandon E; Kennedy, Mia H E; FitzPatrick, Rachael D; Gauthier, Courtney M; Shin, Dongju; Gatti, Dominique M; Conway, Kate M E; Reynolds, Lisa A.
Afiliación
  • Brosschot TP; Department of Biochemistry and Microbiology, University of Victoria, Victoria, Canada.
  • Lawrence KM; Department of Biochemistry and Microbiology, University of Victoria, Victoria, Canada.
  • Moeller BE; Department of Biochemistry and Microbiology, University of Victoria, Victoria, Canada.
  • Kennedy MHE; Department of Biochemistry and Microbiology, University of Victoria, Victoria, Canada.
  • FitzPatrick RD; Department of Biochemistry and Microbiology, University of Victoria, Victoria, Canada.
  • Gauthier CM; Department of Biochemistry and Microbiology, University of Victoria, Victoria, Canada.
  • Shin D; Department of Biochemistry and Microbiology, University of Victoria, Victoria, Canada.
  • Gatti DM; Department of Biochemistry and Microbiology, University of Victoria, Victoria, Canada.
  • Conway KME; Department of Biochemistry and Microbiology, University of Victoria, Victoria, Canada.
  • Reynolds LA; Department of Biochemistry and Microbiology, University of Victoria, Victoria, Canada.
PLoS Negl Trop Dis ; 15(1): e0009052, 2021 01.
Article en En | MEDLINE | ID: mdl-33471793
Intestinal helminth infection can impair host resistance to co-infection with enteric bacterial pathogens. However, it is not known whether helminth drug-clearance can restore host resistance to bacterial infection. Using a mouse helminth-Salmonella co-infection system, we show that anthelmintic treatment prior to Salmonella challenge is sufficient to restore host resistance to Salmonella. The presence of the small intestine-dwelling helminth Heligmosomoides polygyrus at the point of Salmonella infection supports the initial establishment of Salmonella in the small intestinal lumen. Interestingly, if helminth drug-clearance is delayed until Salmonella has already established in the small intestinal lumen, anthelmintic treatment does not result in complete clearance of Salmonella. This suggests that while the presence of helminths supports initial Salmonella colonization, helminths are dispensable for Salmonella persistence in the host small intestine. These data contribute to the mechanistic understanding of how an ongoing or prior helminth infection can affect pathogenic bacterial colonization and persistence in the mammalian intestine.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Salmonella / Nematospiroides dubius / Coinfección / Resistencia a la Enfermedad / Helmintiasis / Parasitosis Intestinales Límite: Animals Idioma: En Revista: PLoS Negl Trop Dis Asunto de la revista: MEDICINA TROPICAL Año: 2021 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Salmonella / Nematospiroides dubius / Coinfección / Resistencia a la Enfermedad / Helmintiasis / Parasitosis Intestinales Límite: Animals Idioma: En Revista: PLoS Negl Trop Dis Asunto de la revista: MEDICINA TROPICAL Año: 2021 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos