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Effects of subthalamic deep brain stimulation on fixational eye movements in Parkinson's disease.
Beylergil, Sinem Balta; Murray, Jordan; Noecker, Angela M; Gupta, Palak; Kilbane, Camilla; McIntyre, Cameron C; Shaikh, Aasef G; Ghasia, Fatema F.
Afiliación
  • Beylergil SB; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
  • Murray J; National VA Parkinson Consortium Center, Neurology Service, Daroff-Dell'Osso Ocular Motility and Vestibular Laboratory, Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA.
  • Noecker AM; Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA.
  • Gupta P; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
  • Kilbane C; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
  • McIntyre CC; National VA Parkinson Consortium Center, Neurology Service, Daroff-Dell'Osso Ocular Motility and Vestibular Laboratory, Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA.
  • Shaikh AG; Department of Neurology, Case Western Reserve University, Cleveland, OH, USA.
  • Ghasia FF; Movement Disorders Center, Neurological Institute, University Hospitals, Cleveland, OH, USA.
J Comput Neurosci ; 49(3): 345-356, 2021 08.
Article en En | MEDLINE | ID: mdl-33464428
Miniature yoked eye movements, fixational saccades, are critical to counteract visual fading. Fixational saccades are followed by a return saccades forming squarewaves. Present in healthy states, squarewaves, if too many or too big, affect visual stability. Parkinson's disease (PD), where visual deficits are not uncommon, is associated with the squarewaves that are excessive in number or size. Our working hypothesis is that the basal ganglia are at the epicenter of the abnormal fixational saccades and squarewaves in PD; the effects are manifested through their connections to the superior colliculus (affecting saccade frequency and amplitude) and the cerebellum (affecting velocity and amplitude). We predict that the subthalamic deep brain stimulation (DBS) variably affects the amplitude, frequency, and velocity of fixational saccade and that the effect depends on the electrode's proximity or the volume of activated tissue in the subthalamic nucleus' connections with the superior colliculus or the cerebellum. We found that DBS modulated saccade amplitude, frequency, and velocity in 11 PD patients. Although all three parameters were affected, the extent of the effects varied amongst subjects. The modulation was dependent upon the location and size of the electrically activated volume of the subthalamic region.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Núcleo Subtalámico / Estimulación Encefálica Profunda Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Comput Neurosci Asunto de la revista: INFORMATICA MEDICA / NEUROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Núcleo Subtalámico / Estimulación Encefálica Profunda Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Comput Neurosci Asunto de la revista: INFORMATICA MEDICA / NEUROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos