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Structure of SRSF1 RRM1 bound to RNA reveals an unexpected bimodal mode of interaction and explains its involvement in SMN1 exon7 splicing.
Cléry, Antoine; Krepl, Miroslav; Nguyen, Cristina K X; Moursy, Ahmed; Jorjani, Hadi; Katsantoni, Maria; Okoniewski, Michal; Mittal, Nitish; Zavolan, Mihaela; Sponer, Jiri; Allain, Frédéric H-T.
Afiliación
  • Cléry A; Department of Biology, Institute of Biochemistry, ETH Zurich, Zurich, Switzerland. aclery@mol.biol.ethz.ch.
  • Krepl M; Biomolecular NMR Spectroscopy Platform, ETH Zurich, Zurich, Switzerland. aclery@mol.biol.ethz.ch.
  • Nguyen CKX; Institute of Biophysics of the Czech Academy of Sciences, Kralovopolska 135, 612 65, Brno, Czech Republic.
  • Moursy A; Department of Biology, Institute of Biochemistry, ETH Zurich, Zurich, Switzerland.
  • Jorjani H; Department of Biology, Institute of Biochemistry, ETH Zurich, Zurich, Switzerland.
  • Katsantoni M; Computational and Systems Biology, Biozentrum, University of Basel, Basel, Switzerland.
  • Okoniewski M; Computational and Systems Biology, Biozentrum, University of Basel, Basel, Switzerland.
  • Mittal N; Scientific IT Services, ETH Zurich, Zurich, Switzerland.
  • Zavolan M; Computational and Systems Biology, Biozentrum, University of Basel, Basel, Switzerland.
  • Sponer J; Computational and Systems Biology, Biozentrum, University of Basel, Basel, Switzerland.
  • Allain FH; Institute of Biophysics of the Czech Academy of Sciences, Kralovopolska 135, 612 65, Brno, Czech Republic.
Nat Commun ; 12(1): 428, 2021 01 18.
Article en En | MEDLINE | ID: mdl-33462199

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Empalme del ARN / Sitios de Empalme de ARN / Proteína 1 para la Supervivencia de la Neurona Motora / Factores de Empalme Serina-Arginina / Motivo de Reconocimiento de ARN Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Empalme del ARN / Sitios de Empalme de ARN / Proteína 1 para la Supervivencia de la Neurona Motora / Factores de Empalme Serina-Arginina / Motivo de Reconocimiento de ARN Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido