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Characteristics and overall survival in pediatric versus adult skull base chordoma: a population-based study.
Xu, Jordan C; Lehrich, Brandon M; Yasaka, Tyler M; Fong, Brendan M; Hsu, Frank P K; Kuan, Edward C.
Afiliación
  • Xu JC; Department of Neurosurgery, University of California, Irvine, CA, USA.
  • Lehrich BM; Medical Scientist Training Program, University of Pittsburgh and Carnegie Mellon University, Pittsburgh, PA, USA.
  • Yasaka TM; Department of Otolaryngology-Head and Neck Surgery, University of California, Irvine, Orange, CA, USA.
  • Fong BM; Department of Neurosurgery, University of California, Irvine, CA, USA.
  • Hsu FPK; Department of Neurosurgery, University of California, Irvine, CA, USA.
  • Kuan EC; Department of Neurosurgery, University of California, Irvine, CA, USA. eckuan@uci.edu.
Childs Nerv Syst ; 37(6): 1901-1908, 2021 06.
Article en En | MEDLINE | ID: mdl-33459820
PURPOSE: Less than 5% of chordomas occur in pediatric patients. While many studies have explored the treatment and outcomes of skull base chordomas, few have focused on the differences between pediatric and adult populations. The aim of this study is to analyze the epidemiological variables and clinical outcomes between pediatric and adult skull base chordomas using a large-sample, population-based cancer database. METHODS: The National Cancer Database was queried between 2004 and 2015 for skull base chordomas. We stratified patients as pediatric (<18 years) and adults (≥18 years). We compared several clinical covariates between the two groups. RESULTS: Our cohort consisted of 658 patients, 61 pediatric (9.3%), and 597 adults (90.7%). Pediatric patients were more likely to have larger tumor size (41.4 ± 15.7 mm versus 34.1 ± 15.8 mm, p < 0.01) and universally treated at academic facilities. There was no significant difference in overall survival. CONCLUSIONS: Pediatric skull base chordomas are rare tumors that are managed with aggressive surgical resection, followed by radiation. While there may be difference between tumor presentation, outcomes between pediatric and adult patients are similar.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cordoma / Neoplasias de la Base del Cráneo Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adult / Child / Humans Idioma: En Revista: Childs Nerv Syst Asunto de la revista: NEUROLOGIA / PEDIATRIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cordoma / Neoplasias de la Base del Cráneo Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adult / Child / Humans Idioma: En Revista: Childs Nerv Syst Asunto de la revista: NEUROLOGIA / PEDIATRIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania