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3D Printing of Vascular Tubes Using Bioelastomer Prepolymers by Freeform Reversible Embedding.
Savoji, Houman; Davenport Huyer, Locke; Mohammadi, Mohammad Hossein; Lun Lai, Benjamin Fook; Rafatian, Naimeh; Bannerman, Dawn; Shoaib, Mohammad; Bobicki, Erin R; Ramachandran, Arun; Radisic, Milica.
Afiliación
  • Savoji H; Institute of Biomaterials and Biomedical Engineering, University of Toronto, 170 College Street, Toronto, Ontario M5S 3G9, Canada.
  • Davenport Huyer L; Toronto General Research Institute, University Health Network, University of Toronto, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada.
  • Mohammadi MH; Institute of Biomaterials and Biomedical Engineering, University of Toronto, 170 College Street, Toronto, Ontario M5S 3G9, Canada.
  • Lun Lai BF; Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, Ontario M5S 3E5, Canada.
  • Rafatian N; Toronto General Research Institute, University Health Network, University of Toronto, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada.
  • Bannerman D; Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, Ontario M5S 3E5, Canada.
  • Shoaib M; Toronto General Research Institute, University Health Network, University of Toronto, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada.
  • Bobicki ER; Institute of Biomaterials and Biomedical Engineering, University of Toronto, 170 College Street, Toronto, Ontario M5S 3G9, Canada.
  • Ramachandran A; Toronto General Research Institute, University Health Network, University of Toronto, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada.
  • Radisic M; Institute of Biomaterials and Biomedical Engineering, University of Toronto, 170 College Street, Toronto, Ontario M5S 3G9, Canada.
ACS Biomater Sci Eng ; 6(3): 1333-1343, 2020 03 09.
Article en En | MEDLINE | ID: mdl-33455372
Bioelastomers have been extensively used in tissue engineering applications because of favorable mechanical stability, tunable properties, and chemical versatility. As these materials generally possess low elastic modulus and relatively long gelation time, it is challenging to 3D print them using traditional techniques. Instead, the field of 3D printing has focused preferentially on hydrogels and rigid polyester materials. To develop a versatile approach for 3D printing of elastomers, we used freeform reversible embedding of suspended prepolymers. A family of novel fast photocrosslinakble bioelastomer prepolymers were synthesized from dimethyl itaconate, 1,8-octanediol, and triethyl citrate. Tensile testing confirmed their elastic properties with Young's moduli in the range of 11-53 kPa. These materials supported cultivation of viable cells and enabled adhesion and proliferation of human umbilical vein endothelial cells. Tubular structures were created by embedding the 3D printed microtubes within a secondary hydrogel that served as a temporary support. Upon photocrosslinking and porogen leaching, the polymers were permeable to small molecules (TRITC-dextran). The polymer microtubes were assembled on the 96-well plates custom made by hot-embossing, as a tool to connect multiple organs-on-a-chip. The endothelialization of the tubes was performed to confirm that these microtubes can be utilized as vascular tubes to support parenchymal tissues seeded on them.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Endoteliales / Impresión Tridimensional Límite: Humans Idioma: En Revista: ACS Biomater Sci Eng Año: 2020 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Endoteliales / Impresión Tridimensional Límite: Humans Idioma: En Revista: ACS Biomater Sci Eng Año: 2020 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos