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Changes in motor nerve excitability in acute phase Guillain-Barré syndrome.
Drenthen, Judith; Islam, Badrul; Islam, Zhahirul; Mohammad, Quazi D; Maathuis, Ellen M; Visser, Gerhard H; van Doorn, Pieter A; Blok, Joleen H; Endtz, Hubert P; Jacobs, Bart C.
Afiliación
  • Drenthen J; Depts. of Clinical Neurophysiology, University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Islam B; Laboratory of Gut-Brain Signaling, Laboratory Sciences and Services Division, International Centre for Diarrhoeal Disease Research, (icddr,b), Dhaka, Bangladesh.
  • Islam Z; Laboratory of Gut-Brain Signaling, Laboratory Sciences and Services Division, International Centre for Diarrhoeal Disease Research, (icddr,b), Dhaka, Bangladesh.
  • Mohammad QD; National Institute of Neurosciences and Hospital, Dhaka, Bangladesh.
  • Maathuis EM; Depts. of Clinical Neurophysiology, University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Visser GH; Stichting Epilepsie Instellingen Nederland (SEIN), Heemstede, The Netherlands.
  • van Doorn PA; Neurology, University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Blok JH; Medisch Centrum Eindhoven Veldhoven, Eindhoven, The Netherlands.
  • Endtz HP; Medical microbiology and infectious diseases, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Jacobs BC; Neurology, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Muscle Nerve ; 63(4): 546-552, 2021 04.
Article en En | MEDLINE | ID: mdl-33452679
BACKGROUND: The most common subtypes of Guillain-Barré syndrome (GBS) are acute inflammatory demyelinating polyneuropathy (AIDP) and acute motor axonal neuropathy (AMAN). In the first days after the onset of weakness, standard nerve conduction studies (NCS) may not distinguish GBS subtypes. Reduced nerve excitability may be an early symptom of nerve dysfunction, which can be determined with the compound muscle action potential (CMAP) scan. The aim of this study was to explore whether early changes in motor nerve excitability in GBS patients are related to various subtypes. METHODS: Prospective case-control study in 19 GBS patients from The Netherlands and 22 from Bangladesh. CMAP scans were performed within 2 days of hospital admission and NCS 7-14 days after onset of weakness. CMAP scans were also performed in age- and country-matched controls. RESULTS: CMAP scan patterns of patients who were classified as AMAN were distinctly different compared to the CMAP scan patterns of the patients who were classified as AIDP. The most pronounced differences were found in the stimulus intensity parameters. CONCLUSIONS: CMAP scans made at hospital admission demonstrate several characteristics that can be used as an early indicator of GBS subtype.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema Nervioso Periférico / Síndrome de Guillain-Barré / Tejido Nervioso / Conducción Nerviosa Tipo de estudio: Observational_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Muscle Nerve Año: 2021 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema Nervioso Periférico / Síndrome de Guillain-Barré / Tejido Nervioso / Conducción Nerviosa Tipo de estudio: Observational_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Muscle Nerve Año: 2021 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos