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Outcomes of a uniformly active approach to infants born at 22-24 weeks of gestation.
Söderström, Fanny; Normann, Erik; Jonsson, Maria; Ågren, Johan.
Afiliación
  • Söderström F; Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden fanny.soderstrom@kbh.uu.se.
  • Normann E; Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
  • Jonsson M; Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
  • Ågren J; Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Arch Dis Child Fetal Neonatal Ed ; 106(4): 413-417, 2021 Jul.
Article en En | MEDLINE | ID: mdl-33452221
OBJECTIVE: To determine survival and outcomes in infants born at 22-24 weeks of gestation in a centre with a uniformly active approach to management of extremely preterm infants. STUDY DESIGN: Single-centre retrospective cohort study including infants born 2006-2015. Short-term morbidities assessed included retinopathy of prematurity, necrotising enterocolitis, patent ductus arteriosus, intraventricular haemorrhage, periventricular malacia and bronchopulmonary dysplasia. Neurodevelopmental outcomes assessed included cerebral palsy, visual impairment, hearing impairment and developmental delay. RESULTS: Total survival was 64% (143/222), ranging from 52% at 22 weeks to 70% at 24 weeks. Of 133 (93%) children available for follow-up at 2.5 years corrected age, 34% had neurodevelopmental impairment with 11% classified as moderately to severely impaired. Treatment-requiring retinopathy of prematurity, severe bronchopulmonary dysplasia, visual impairment and developmental delay correlated with lower gestational age. CONCLUSIONS: A uniformly active approach to all extremely preterm infants results in survival rates that are not distinctly different across the gestational ages of 22-24 weeks and more than 50% survival even in infants at 22 weeks. The majority were unimpaired at 2.5 years, suggesting that such an approach does not result in higher rates of long-term adverse neurological outcome.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Recien Nacido Extremadamente Prematuro / Trastornos del Neurodesarrollo / Enfermedades del Prematuro Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Child / Child, preschool / Female / Humans / Infant / Male / Newborn Idioma: En Revista: Arch Dis Child Fetal Neonatal Ed Asunto de la revista: PEDIATRIA / PERINATOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Recien Nacido Extremadamente Prematuro / Trastornos del Neurodesarrollo / Enfermedades del Prematuro Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Child / Child, preschool / Female / Humans / Infant / Male / Newborn Idioma: En Revista: Arch Dis Child Fetal Neonatal Ed Asunto de la revista: PEDIATRIA / PERINATOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Reino Unido