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MAT2A Inhibition Blocks the Growth of MTAP-Deleted Cancer Cells by Reducing PRMT5-Dependent mRNA Splicing and Inducing DNA Damage.
Kalev, Peter; Hyer, Marc L; Gross, Stefan; Konteatis, Zenon; Chen, Chi-Chao; Fletcher, Mark; Lein, Max; Aguado-Fraile, Elia; Frank, Victoria; Barnett, Amelia; Mandley, Everton; Goldford, Joshua; Chen, Yue; Sellers, Katie; Hayes, Sebastian; Lizotte, Kate; Quang, Phong; Tuncay, Yesim; Clasquin, Michelle; Peters, Rachel; Weier, Jaclyn; Simone, Eric; Murtie, Joshua; Liu, Wei; Nagaraja, Raj; Dang, Lenny; Sui, Zhihua; Biller, Scott A; Travins, Jeremy; Marks, Kevin M; Marjon, Katya.
Afiliación
  • Kalev P; Biology, Agios Pharmaceuticals, Inc., Cambridge, MA 02139, USA.
  • Hyer ML; Pharmacology, Agios Pharmaceuticals, Inc., Cambridge, MA 02139, USA.
  • Gross S; Biochemistry and Biophysics, Agios Pharmaceuticals, Inc., Cambridge, MA 02139, USA.
  • Konteatis Z; Chemistry, Agios Pharmaceuticals, Inc., Cambridge, MA 02139, USA.
  • Chen CC; Bioinformatics, Agios Pharmaceuticals, Inc., Cambridge, MA 02139, USA.
  • Fletcher M; Bioinformatics, Agios Pharmaceuticals, Inc., Cambridge, MA 02139, USA.
  • Lein M; Drug Metabolism and Pharmacokinetics, Agios Pharmaceuticals, Inc., Cambridge, MA 02139, USA.
  • Aguado-Fraile E; Clinical Biomarkers, Agios Pharmaceuticals, Inc., Cambridge, MA 02139, USA.
  • Frank V; Biology, Agios Pharmaceuticals, Inc., Cambridge, MA 02139, USA.
  • Barnett A; Biology, Agios Pharmaceuticals, Inc., Cambridge, MA 02139, USA.
  • Mandley E; Pharmacology, Agios Pharmaceuticals, Inc., Cambridge, MA 02139, USA.
  • Goldford J; Cell Metabolism, Agios Pharmaceuticals, Inc., Cambridge, MA 02139, USA.
  • Chen Y; Drug Metabolism and Pharmacokinetics, Agios Pharmaceuticals, Inc., Cambridge, MA 02139, USA.
  • Sellers K; Cell Metabolism, Agios Pharmaceuticals, Inc., Cambridge, MA 02139, USA.
  • Hayes S; Cell Metabolism, Agios Pharmaceuticals, Inc., Cambridge, MA 02139, USA.
  • Lizotte K; Cell Metabolism, Agios Pharmaceuticals, Inc., Cambridge, MA 02139, USA.
  • Quang P; Biology, Agios Pharmaceuticals, Inc., Cambridge, MA 02139, USA.
  • Tuncay Y; Biology, Agios Pharmaceuticals, Inc., Cambridge, MA 02139, USA.
  • Clasquin M; Cell Metabolism, Agios Pharmaceuticals, Inc., Cambridge, MA 02139, USA.
  • Peters R; Toxicology, Agios Pharmaceuticals, Inc., Cambridge, MA 02139, USA.
  • Weier J; Biology, Agios Pharmaceuticals, Inc., Cambridge, MA 02139, USA.
  • Simone E; Chemistry, Manufacturing and Control, Agios Pharmaceuticals, Inc., Cambridge, MA 02139, USA.
  • Murtie J; Biology, Agios Pharmaceuticals, Inc., Cambridge, MA 02139, USA; Pharmacology, Agios Pharmaceuticals, Inc., Cambridge, MA 02139, USA.
  • Liu W; Bioinformatics, Agios Pharmaceuticals, Inc., Cambridge, MA 02139, USA.
  • Nagaraja R; Drug Metabolism and Pharmacokinetics, Agios Pharmaceuticals, Inc., Cambridge, MA 02139, USA.
  • Dang L; Biochemistry and Biophysics, Agios Pharmaceuticals, Inc., Cambridge, MA 02139, USA.
  • Sui Z; Chemistry, Agios Pharmaceuticals, Inc., Cambridge, MA 02139, USA.
  • Biller SA; Chemistry, Agios Pharmaceuticals, Inc., Cambridge, MA 02139, USA.
  • Travins J; Chemistry, Agios Pharmaceuticals, Inc., Cambridge, MA 02139, USA.
  • Marks KM; Biology, Agios Pharmaceuticals, Inc., Cambridge, MA 02139, USA.
  • Marjon K; Biology, Agios Pharmaceuticals, Inc., Cambridge, MA 02139, USA. Electronic address: katya.marjon@agios.com.
Cancer Cell ; 39(2): 209-224.e11, 2021 02 08.
Article en En | MEDLINE | ID: mdl-33450196
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína-Arginina N-Metiltransferasas / Daño del ADN / ARN Mensajero / Empalme del ARN / Purina-Nucleósido Fosforilasa / Inhibidores Enzimáticos / Metionina Adenosiltransferasa Límite: Animals / Humans Idioma: En Revista: Cancer Cell Asunto de la revista: NEOPLASIAS Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína-Arginina N-Metiltransferasas / Daño del ADN / ARN Mensajero / Empalme del ARN / Purina-Nucleósido Fosforilasa / Inhibidores Enzimáticos / Metionina Adenosiltransferasa Límite: Animals / Humans Idioma: En Revista: Cancer Cell Asunto de la revista: NEOPLASIAS Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos