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Does cognitive behavioral therapy for anxiety disorders assist the discontinuation of benzodiazepines among patients with anxiety disorders? A systematic review and meta-analysis.
Takeshima, Masahiro; Otsubo, Tempei; Funada, Daisuke; Murakami, Maki; Usami, Takashi; Maeda, Yoshihiro; Yamamoto, Taisuke; Matsumoto, Toshihiko; Shimane, Takuya; Aoki, Yumi; Otowa, Takeshi; Tani, Masayuki; Yamanaka, Gaku; Sakai, Yojiro; Murao, Tomohiko; Inada, Ken; Yamada, Hiroki; Kikuchi, Toshiaki; Sasaki, Tsukasa; Watanabe, Norio; Mishima, Kazuo; Takaesu, Yoshikazu.
Afiliación
  • Takeshima M; Department of Neuropsychiatry, Akita University Graduate School of Medicine, Akita, Japan.
  • Otsubo T; Department of Psychiatry, Tokyo Women's Medical University Medical Center East, Tokyo, Japan.
  • Funada D; Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan.
  • Murakami M; Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan.
  • Usami T; Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan.
  • Maeda Y; Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan.
  • Yamamoto T; Department of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan.
  • Matsumoto T; Department of Drug Dependence Research, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.
  • Shimane T; Department of Drug Dependence Research, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.
  • Aoki Y; Psychiatric & Mental Health Nursing, Graduate School of Nursing, St. Luke's International University, Tokyo, Japan.
  • Otowa T; Department of Psychiatry, NTT Medical Center Tokyo, Tokyo, Japan.
  • Tani M; Department of Psychiatry, Oouchi Hospital, Tokyo, Japan.
  • Yamanaka G; Department of Psychiatry, Yokohama Clinic, Yokohama, Japan.
  • Sakai Y; Department of Psychiatry, Akasaka Clinic, Tokyo, Japan.
  • Murao T; Department of Psychiatry, Tokyo Women's Medical University Medical Center East, Tokyo, Japan.
  • Inada K; Department of Psychiatry, Tokyo Women's Medical University, Tokyo, Japan.
  • Yamada H; Department of Psychiatry, Showa University Northern Yokohama Hospital, Yokohama, Japan.
  • Kikuchi T; Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
  • Sasaki T; Laboratory of Health Education, Graduate School of Education, The University of Tokyo, Tokyo, Japan.
  • Watanabe N; Department of Health Promotion and Human Behavior and of Clinical Epidemiology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Mishima K; Department of Neuropsychiatry, Akita University Graduate School of Medicine, Akita, Japan.
  • Takaesu Y; Department of Neuropsychiatry, Kyorin University School of Medicine, Tokyo, Japan.
Psychiatry Clin Neurosci ; 75(4): 119-127, 2021 Apr.
Article en En | MEDLINE | ID: mdl-33448517
Long-term use of benzodiazepines (BZD) is not recommended for the treatment of anxiety disorders. Cognitive behavioral therapy (CBT) is an effective treatment option for discontinuation of BZD in patients with anxiety disorders. This systematic review and meta-analysis sought to clarify whether CBT is effective for discontinuing BZD anxiolytics in patients with anxiety disorders. This study was preregistered with PROSPERO (registration number: CRD42019125263). A literature search of major electronic databases was conducted in December 2018. Three randomized controlled trials were included in this review, and meta-analyses were performed. The proportion of discontinuing BZD anxiolytics was significantly higher in the CBT plus gradual tapering group than in the gradual tapering alone group, both in the short term (3 months after allocation; number needed to treat: 3.2, 95% confidence interval [CI]: 2.1 to 7.1; risk ratio: 1.96, 95%CI: 1.29 to 2.98, P = 0.002, three studies) and long term (6 to 12 months after allocation; number needed to treat: 2.8, 95%CI: 1.9 to 5.3; risk ratio: 2.16, 95%CI: 1.41 to 3.32, P = 0.0004, three studies). CBT may be effective for discontinuing BZD anxiolytics, both in the short term and in the long term after the allocation. Further studies with larger sample sizes are necessary to draw definitive conclusions regarding the efficacy and safety of CBT for discontinuing BZD anxiolytics in patients with anxiety disorders.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos de Ansiedad / Benzodiazepinas / Terapia Cognitivo-Conductual / Evaluación de Resultado en la Atención de Salud Tipo de estudio: Clinical_trials / Systematic_reviews Límite: Humans Idioma: En Revista: Psychiatry Clin Neurosci Asunto de la revista: NEUROLOGIA / PSIQUIATRIA Año: 2021 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Australia
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos de Ansiedad / Benzodiazepinas / Terapia Cognitivo-Conductual / Evaluación de Resultado en la Atención de Salud Tipo de estudio: Clinical_trials / Systematic_reviews Límite: Humans Idioma: En Revista: Psychiatry Clin Neurosci Asunto de la revista: NEUROLOGIA / PSIQUIATRIA Año: 2021 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Australia