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Improving antibiotic treatment of bacterial biofilm by hyperbaric oxygen therapy: Not just hot air.
Jensen, P Ø; Møller, S A; Lerche, C J; Moser, C; Bjarnsholt, T; Ciofu, O; Faurholt-Jepsen, D; Høiby, N; Kolpen, M.
Afiliación
  • Jensen PØ; Department of Clinical Microbiology, Rigshospitalet, 2100, Copenhagen, Denmark.
  • Møller SA; Costerton Biofilm Center, Department of Immunology and Microbiology, Faculty of Health Sciences University of Copenhagen, 2200, Copenhagen, Denmark.
  • Lerche CJ; Department of Clinical Microbiology, Rigshospitalet, 2100, Copenhagen, Denmark.
  • Moser C; Department of Clinical Microbiology, Rigshospitalet, 2100, Copenhagen, Denmark.
  • Bjarnsholt T; Department of Clinical Microbiology, Rigshospitalet, 2100, Copenhagen, Denmark.
  • Ciofu O; Department of Clinical Microbiology, Rigshospitalet, 2100, Copenhagen, Denmark.
  • Faurholt-Jepsen D; Costerton Biofilm Center, Department of Immunology and Microbiology, Faculty of Health Sciences University of Copenhagen, 2200, Copenhagen, Denmark.
  • Høiby N; Costerton Biofilm Center, Department of Immunology and Microbiology, Faculty of Health Sciences University of Copenhagen, 2200, Copenhagen, Denmark.
  • Kolpen M; Copenhagen Cystic Fibrosis Center, Department of Infectious Diseases, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK2100, Copenhagen, Denmark.
Biofilm ; 1: 100008, 2019 Dec.
Article en En | MEDLINE | ID: mdl-33447795
Bacteria and fungi show substantial increased recalcitrance when growing as infectious biofilms. Chronic infections caused by biofilm growing microorganisms is considered a major problem of modern medicine. New strategies are needed to improve antibiotic treatment of biofilms. We have improved antibiotic treatment of bacterial biofilms by reviving the dormant bacteria and thereby make them susceptible to antibiotics by means of reoxygenation. Here we review the rationale for associating lack of oxygen with low susceptibility in infectious biofilm, and how hyperbaric oxygen therapy may result in reoxygenation leading to enhanced bactericidal activity of antibiotics. We address issues of feasibility and potential adverse effects regarding patient safety and development of resistance. Finally, we propose means for supplying reoxygenation to antibiotic treatment of infectious biofilm with the potential to benefit large groups of patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biofilm Año: 2019 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biofilm Año: 2019 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Países Bajos