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An early experience on the effect of solid organ transplant status on hospitalized COVID-19 patients.
Nair, Vinay; Jandovitz, Nicholas; Hirsch, Jamie S; Abate, Mersema; Satapathy, Sanjaya K; Roth, Nitzan; Miyara, Santiago J; Guevara, Sara; Kressel, Adam M; Xiang, Alec; Wu, Grace; Butensky, Samuel D; Lin, David; Williams, Stephanie; Bhaskaran, Madhu C; Majure, David T; Grodstein, Elliot; Lau, Lawrence; Nair, Gayatri; Fahmy, Ahmed E; Winnick, Aaron; Breslin, Nadine; Berlinrut, Ilan; Molmenti, Christine; Becker, Lance B; Malhotra, Prashant; Gautam-Goyal, Pranisha; Lima, Brian; Maybaum, Simon; Shah, Samit K; Takegawa, Ryosuke; Hayashida, Kei; Shinozaki, Koichiro; Teperman, Lewis W; Molmenti, Ernesto P.
Afiliación
  • Nair V; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York.
  • Jandovitz N; North Shore University Hospital, Northwell Health, Manhasset, New York.
  • Hirsch JS; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York.
  • Abate M; Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.
  • Satapathy SK; Department of Information Services, Northwell Health, New Hyde Park, New York.
  • Roth N; Department of Surgery, Northwell Health, Manhasset, New York.
  • Miyara SJ; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York.
  • Guevara S; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York.
  • Kressel AM; North Shore University Hospital, Northwell Health, Manhasset, New York.
  • Xiang A; Department of Surgery, Northwell Health, Manhasset, New York.
  • Wu G; Department of Surgery, Northwell Health, Manhasset, New York.
  • Butensky SD; Department of Surgery, Northwell Health, Manhasset, New York.
  • Lin D; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York.
  • Williams S; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York.
  • Bhaskaran MC; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York.
  • Majure DT; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York.
  • Grodstein E; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York.
  • Lau L; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York.
  • Nair G; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York.
  • Fahmy AE; North Shore University Hospital, Northwell Health, Manhasset, New York.
  • Winnick A; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York.
  • Breslin N; North Shore University Hospital, Northwell Health, Manhasset, New York.
  • Berlinrut I; Long Island Jewish Medical Center, Northwell Health, New Hyde Park, New York.
  • Molmenti C; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York.
  • Becker LB; North Shore University Hospital, Northwell Health, Manhasset, New York.
  • Malhotra P; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York.
  • Gautam-Goyal P; Department of Surgery, Northwell Health, Manhasset, New York.
  • Lima B; North Shore University Hospital, Northwell Health, Manhasset, New York.
  • Maybaum S; North Shore University Hospital, Northwell Health, Manhasset, New York.
  • Shah SK; Long Island Jewish Medical Center, Northwell Health, New Hyde Park, New York.
  • Takegawa R; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York.
  • Hayashida K; Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.
  • Shinozaki K; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York.
  • Teperman LW; North Shore University Hospital, Northwell Health, Manhasset, New York.
  • Molmenti EP; Long Island Jewish Medical Center, Northwell Health, New Hyde Park, New York.
Am J Transplant ; 21(7): 2522-2531, 2021 07.
Article en En | MEDLINE | ID: mdl-33443778
We compared the outcome of COVID-19 in immunosuppressed solid organ transplant (SOT) patients to a transplant naïve population. In total, 10 356 adult hospital admissions for COVID-19 from March 1, 2020 to April 27, 2020 were analyzed. Data were collected on demographics, baseline clinical conditions, medications, immunosuppression, and COVID-19 course. Primary outcome was combined death or mechanical ventilation. We assessed the association between primary outcome and prognostic variables using bivariate and multivariate regression models. We also compared the primary endpoint in SOT patients to an age, gender, and comorbidity-matched control group. Bivariate analysis found transplant status, age, gender, race/ethnicity, body mass index, diabetes, hypertension, cardiovascular disease, COPD, and GFR <60 mL/min/1.73 m2 to be significant predictors of combined death or mechanical ventilation. After multivariate logistic regression analysis, SOT status had a trend toward significance (odds ratio [OR] 1.29; 95% CI 0.99-1.69, p = .06). Compared to an age, gender, and comorbidity-matched control group, SOT patients had a higher combined risk of death or mechanical ventilation (OR 1.34; 95% CI 1.03-1.74, p = .027).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante de Órganos / COVID-19 Tipo de estudio: Prognostic_studies Límite: Adult / Humans Idioma: En Revista: Am J Transplant Asunto de la revista: TRANSPLANTE Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante de Órganos / COVID-19 Tipo de estudio: Prognostic_studies Límite: Adult / Humans Idioma: En Revista: Am J Transplant Asunto de la revista: TRANSPLANTE Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos